Other

Sandia Corporation

University of Virginia Patent Foundation

Veridian Erim International, Inc.

Pacific Sierra Research

Charles E Daitch

Bouvard Hosticka

L Roger Mason, Jr

C Jeffrey Brinker

Wayne A Bryden

Lawrence James DeLucas

Carol S Ashley

Kenneth J Shea

Ming Luo

Peter F Scholl

Darryl Y Sasaki

Daniel J Rush

Pamela M Norris

Jack S Brenizer

Eric Black

Jack S Brenizer, Jr

Pamela N Norris

Techniques to modify and apply aerogel coatings are described, including the application of spray-coated aerogels. The approach eliminates several of the wet chemical techniques previously needed for processes such as MALDI processing, and simplifies the automation of processes such as continuous monitoring in a sensor based format. With respect to MALDI processing, the preferred embodiment uses an acid-doped silica aerogel coated tape as the collection media as well as the matrix support. Although aerogels are disclosed as a preferred matrix material, other materials may alternatively be used, including linoleic acids, oleic acids, PEG (polyelthylene glycol), preferably in tape format.

Aerogels and other coatings as collection media and matrix supports for MALDI-MS applications

Smart aerogel, an aerogel material doped with special bio-affinity compounds to providing means of unique collection, detection and identification of bioaerosols, including bacteria, viruses, toxins, and other bioaerosols. Aerogels, extremely low density and highly porous materials with a complex pore structure, are used as an intelligent detection material by incorporating specific bioaffinity pharmaceuticals directly into the matrix. The complex pore structure contains micropores, mesopores, and macropores in an open pore structure. The opening pore structure of the aerogel is used to create docking sites by linking high affinity pharmaceuticals that specifically bind only to certain bioaerosols. The high internal surface area of the aerogel and the extremely low density provides abundant receptor sites per unit mesopore for a high bioaerosol-receptor interaction, yet in a manner which will reduce possible damage and destruction to the bioaerosols captured.

Smart aerogel

Atmospheric Samplers are disclosed using aerogel filter material. The samplers include one or more cascaded impact sample stations with discs of aerogel as the targets. Ambient air carrying particulate matter is introduced into the sampler and the particles are captured by the aerogel in its pore structure. In certain embodiments, the aerogel filter is next transported to a position where it is fragmented by a spray of water. The fragmented aerogel and the captured particles are transported in the fragmenting water from the sampler for analysis. In one embodiment, the sampler is segmented with alternate nozzle and filter segments for easy assembly, sampling and disassembly for analysis of the captured particles in aerogel filters positions below the nozzles.

Multi-stage sampler concentrator

A method is provided for molecularly imprinting the surface of a sol-gel material, by forming a solution comprised of a sol-gel material, a solvent, an imprinting molecule, and a functionalizing siloxane monomer of the form Si(OR).sub.3-n X.sub.n, wherein n is an integer between zero and three and X is a functional group capable of reacting with the imprinting molecule, evaporating the solvent, and removing the imprinting molecule to form the molecularly imprinted metal oxide sol-gel material. The use of metal oxide sol-gels allows the material porosity, pore size, density, surface area, hardness, electrostatic charge, polarity, optical density, and surface hydrophobicity to be tailored and be employed as sensors and in catalytic and separations operations.

Molecular receptors in metal oxide sol-gel materials prepared via

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Charlottesville, VA, United States of America

Charles E Daitch