Ventana Medical Systems, Inc.

Blazer International

3m Innovative Properties Company

Other

Anthony Manufacturing Corp.

Copernicus, LLC

Hyrad Corporation

Rain Bird Corporation

Charles Daniel Lemme

William L Richards

Wayne A Showalter

Kurt Reinhardt

Andrew Ghusson

Glen Ward

Kimberly Christensen

Austin Micheil Ashby

Devon C Campbell

Vince Rizzo

Miroslav Holubec

Kendall B Hendrick

Parula Mehta

Brandon Ambler

Matthew Freeman

Rick Griebel

Chris Borchert

Wayne Showalter

Thomas M Grogan

Charles Nathan Hassen

Keith G Copeland

William Ross Humphreys

Phillip C Miller

Tracy R Lemme

Marc G Langlois

Vincent R Rizzo

David Bryant

Ethel R Macrea

Fredrick J Furrer

Brian Howard Kram

Stephen Earl Mead

Paul Richards

Anthony Ford

Michael Albert McAfee

Anthony L Hartman

Matthew S Prucinsky

Darin McDaniel

Brian J McGraw

Bronwen Heilman

Chad Wilkinson

Bobbi Druyor-Sanchez

Rodney Kugizaki

Mark J Mayer

Catherine Wolf

Derek Michael Nations

Alain L Larson

Mirek Holubec

Frederick J Furrer

Philip C Miller

Jerry D Lawyer

John W Ingham, Jr

David E Steimle

Vincent J Rizzo, Jr

Lisa Jensen-Long

Daniel C Lemme

Kevin Knapp

Vincent Rizzo

Devon Campbell

Vince R Rizzo

An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.

Automated high volume slide processing system

An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples.

Apparatus and method for biological sample processing

A fluid dispenser useful in automated biological reaction systems comprising a barrel having a reservoir chamber, the barrel having an upper portion and a lower portion, a cap located on top of the upper portion of the barrel and connected to the reservoir chamber, the cap having an external surface with at least one hole therethrough, a valve comprising a biasing member and a hole sealer, the valve being located in the hole in the cap at the point where a downward force is applied against the cap, a coupler having a dispense chamber, the coupler being coaxial with the barrel and wherein the barrel lower portion moves into the dispense chamber during dispensing of fluid, and a vent located between the cap and the reservoir chamber, the vent including a vent opening and a vent material composed of oliophobic material.

Method and apparatus for modifying pressure within a fluid dispenser

An automated slide processing apparatus includes a plurality of work stations arranged in a stack, and a transport/elevator for transporting slides between the various work stations.

Automated high volume slide staining system

Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent, wash and coverslipping solutions brought to the slides. Alternatively, the slides are held in fixed position, while the reagent, wash and coverslipping solutions brought to the slides.

Automated molecular pathology apparatus having fixed slide platforms

The invention is directed to a method of contacting a biological sample with a solution, comprising the steps of moving a curved surface wetted with the solution in proximity to the biological sample whereby the distance separating the wetted curved surface and the biological sample is sufficient to form a moving liquid meniscus layer between the two. The invention is also directed to an apparatus for contacting a biological sample suspected of containing a biomarker with a solution, comprising a platform for supporting a microscope slide having a biological sample thereon; a translating cap having a curved lower surface positioned above the platform, the curved lower surface being in proximity to a biological sample when in operation; means for moving the translating cap back and forth over the biological sample; and means for applying and removing liquid to and from the cap.

Method and apparatus for applying fluids to a biological sample

The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion process used to stain tissue. The invention comprises a method of tissue staining by applying an electric field to a tissue sample in the presence of an electrolyte and biomolecular conjugates of interest suspended in the electrolyte. Typical staining times are reduced to seconds as opposed to 30-120 minutes common in the prior art. The invention is also directed to devices for performing the method.

Apparatus for electrophoretic in situ tissue staining

An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.

Automated biological reaction apparatus

Growing community of inventors

Tucson, AZ, United States of America

Charles Daniel Lemme