The Boc Group, Inc.

Other

Charles D Wiseman

William M Theisen

Alex Kharazi

The invention provides, in part, novel SV-BR cancer cell lines. The invention provides a novel cell line SV-BR-1 deposited under ATCC PTA-1712 and SV-BR-1-GM cells deposited under ATCC PTA-1713. The invention further relates to therapeutic and non-therapeutic uses of the novel cell lines. Therapeutic uses include the use of SV-BR cell lines as cancer vaccines, and in particular, or the treatment of cancer.

Breast cancer cell lines and uses thereof

A method is disclosed for producing a flexible microcircuit of a size usable in vivo in the arterial or venous tract of a human. The method comprises forming, by various photoresist techniques, conductive runs on a polyimide base of about 1-2 mils thickness. Each end of a flexible microcircuit has minute holes formed therein for connection to an electronic chip and to hard wiring. The method produces holes in the conductive runs for the electronic chip connection of about 0.002 inches in diameter and holes about 0.016 inches in diameter at the end for wiring.

Method of making a flexible microcircuit

A method is disclosed for bonding a minute semiconductor device to the freestanding end of a flexible microcircuit. The method generally comprises a series of steps including initially bonding the semiconductor device to a substrate for handling during the further progression of steps. An extremely minute conductive ball is bonded to one or more conductive surfaces of the semiconductor device and an upwardly depending pigtail is formed atop each of the conductive balls. The flexible microcircuit, having holes in predetermined locations and in numbers corresponding to the upwardly depending pigtails, is positioned atop those pigtails such that a portion of each pigtail protrudes through the flexible microcircuit. Another minute conductive ball is thereafter applied to each of those portions of pigtails protruding through the flexible microcircuit, thus sandwiching the microcircuit between the conductive balls. The final result is a semiconductor device attached to the distal, free end of the flexible microcircuit of sufficient minuteness such that the semiconductor and distal end of the microcircuit can be inserted into a patient's blood vessel for in vivo detection and monitoring of various parameters.

Growing community of inventors

Cottage Grove, WI, United States of America

Charles D Wiseman