University of Hawai'i

Wayne State University

Charles D Smith

Richard E Moore

Gregory M Patterson

Thomas Hughes Corbett

Susan L Mooberry

Frederick A Valeriote

Trimurtulu Golakoti

Shmuel Carmeli

Lucille H Kimura

A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods for producing novel cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided, as are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells. Further provided are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.

Cryptophycins

Novel scytophycin compounds and compositions are disclosed, along with methods of making and using the new compounds. Methods for preparing the new scytophycin compounds from new strains of the blue-green algae Scytonema ocellatum, Scytonema burmanicum and purified cultures of the algae are also provided. The scytophycins are useful as anti-cancer agents, antifungal agents and for cell research purposes.

Scytophycin compounds, compositions and methods for their production and

Growing community of inventors

Feasterville, PA, United States of America

Charles D Smith