Other

Mattel, Inc.

Apogee Biotechnology Corporation

The Penn State Research Foundation

Hewlett-packard Development Company, L.p.

Cpi Excavating, Inc.

The Pennsylvania State University

The Pennsylvania State Research Foundation

Charles D Smith

Kevin J French

Yan Zhuang

Donald J Fasen

William R Howell

Jon Paul Castiglione

David S Lawrence

David A Antonetti

Jeffrey M Sundstrom

Lynn W Maines

Gregory Coventry

Timothy Joseph Trapp

John S Canna

Richard Lee Hilton

Stewart R Wyatt

Curt Nelson Van Lydegraf

Julie Catherine Hogan

Mark John Simms

James P Meade

Michael Clinton Allyn

Juliette Marlene Welch

Christopher D Cimerman

R Alexis Takasugi

Matthew Alan Szymanski

Jennifer M Long

Tracy Ann Sauerwein

James A Bishop, Jr

Lawrence Martin Hopcia

William R Hewitt

Fintan Buckley

Thomas Carter

Kimberly K Kroll

Paula D Repman

Jong K Yun

Craig Raese

Elisabeth Krisel

James A Bishop

Municipal valve key which includes a valve actuator engaging end; an elongated extension portion capable of extending into a municipal valve box; and a handle portion. The valve actuator engaging portion has a valve opening key end and includes a light for illumination of the valve actuator in the valve box.

Lighted municipal valve key

The invention relates to substituted adamantane compounds, pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease.

Sphingosine kinase inhibitors

The present invention relates to an infant play yard with multiple reconfigurations. The infant play yard includes a frame structure that is reconfigurable between a deployed configuration and a storage configuration. Rotatably coupled to the frame structure is a set of legs that are reconfigurable between a deployed configuration and a storage configuration. The infant play yard includes an infant play yard cover that is coupled to the frame structure, the play yard cover having an exterior and an interior. Moreover, the infant play yard further includes a sleeper insert that is removably coupleable to the frame structure. The sleeper insert, when used in conjunction with the frame structure, is disposed between the sidewalls of the play yard cover. The sleeper insert is configured with locking covers that are removably coupleable to the legs of the play yard frame. The locking covers are connected by a resilient tether so that the locking covers easily snap into the proper locking location on the legs of the play yard frame.

Reconfigurable infant play yard

Hinged assemblies, and children's products including at least one hinged assembly, include a base member and a hinged member operatively and pivotally coupled to the base member to define a hinge. The hinge is configured to release if an obstruction is positioned between the hinged member and the base member while the hinged member is being closed and if a closing torque is greater than or equal to a release torque. The hinge also may be configured to not release when an opening torque is applied when the hinged member is in its open position even when the opening torque is greater than the release torque.

Pinch-relief hinged assemblies and children's products including pinch-relief hinged assemblies

The invention relates to prodrugs of hydroxyl-substituted adamantane compounds, pharmaceutical compositions thereof, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease.

Sphingosine kinase inhibitor prodrugs

A utility trailer that includes a main compartment, an aft compartment, a hitch and jack assembly to attach it to a vehicle, and a number of components that will assist an individual in both shredding brush and branches as needed and also removing the resulting residue quickly and easily with use of various control boxes attached to the utility trailer. The trailer also includes a top-mounted shoot opening for throwing brush and debris into the utility trailer and conveyor belt system located within the main compartment for moving debris within the main compartment onto a pulled-out debris tray. A fold-down interior door is located within the main compartment and usually covers the conveyor belt system. Furthermore, a debris pusher blade is also located within the main compartment and can be utilized to push debris out of the main compartment by attached controls.

Utility trailer

The invention includes processes mainly for the treatment of a inflammatory diseases, such as inflammatory bowel disease, arthritis, atherosclerosis, asthma, allergy, inflammatory kidney disease, circulatory shock, multiple sclerosis, chronic obstructive pulmonary disease, skin inflammation, periodontal disease, psoriasis and T cell-mediated diseases of immunity, including allergic encephalomyelitis, allergic neuritis, transplant allograft rejection, graft versus host disease, myocarditis, thyroiditis, nephritis, systemic lupus erthematosus, and insulin-dependent diabetes mellitus. The processes involve treating a patient with a pharmaceutical composition containing an active ingredient that inhibits the activity of sphingosine kinase.

Methods for the treatment and prevention of inflammatory diseases

Methods of treating or preventing a disease or disorder in a subject are provided by the present invention which include administering a composition including a therapeutically effective amount of a protein kinase C (PKC) zeta inhibitor. A disease or disorder treated or prevented by administration of a PKC zeta inhibitor is characterized by abnormal vascular permeability. Diseases or disorders treated or prevented by administration of a composition including a therapeutically effective amount of a PKC zeta inhibitor include cancer, an ischemic condition and microvascular complications of a systemic or local condition in the subject, such as diabetes and/or diabetic macular edema. Additionally, methods of inhibiting PKC zeta are provided which include incubating PKC zeta in vivo, in vitro and/or in silico with a PKC zeta inhibitor.

Protein kinase C zeta inhibition to treat diabetic retinopathy

The present invention is directed toward a product fastening system and, in particular, to a mechanism for securing a toy within product packaging. The packaging may include a toy support platform having a through-hole extending from a first surface to a second surface; a pliable strip configured to pass through the through-hole formed in the toy support platform and a fastener clip that captures the pliable strip to secure the toy to the support platform. The fastener clip may include a base with a plurality of notches formed therein. In operation, the pliable strip is wrapped around the toy object. The ends of the pliable strip are inserted through the through hole and inserted into the notch, becoming secured therein without the need for braiding or twisting the ends of the pliable strip.

Releasable product fastener for product packaging

Protein kinase C zeta inhibition to treat vascular permeability

A parallel data storage device includes a data storage medium having a first cluster and a second cluster. The first cluster includes a first patch and the second cluster includes a second patch. The parallel data storage device also includes a first reader for reading the first patch of the first cluster and a second reader for reading the second patch of the second cluster. A first multiplexer is used for addressing the first cluster while a second multiplexer is used for addressing the second cluster. The first and second readers are arranged in a single column such that the first reader is electrically connected to the first multiplexer and the second reader is electrically connected to the second multiplexer.

Parallel data storage device

Growing community of inventors

Mount Pleasant, SC, United States of America

Charles D Smith