Rutgers, The State University of New Jersey

University of Hawai'i

Other

Pxe International, Inc.

Charles D Boyd

Katalin Csiszar

Chi-Tang Ho

Robert T Rosen

Geetha Ghai

Olivier LeSaux

Zsolt Urban

Sharon Terry

Kuang Yu Chen

Martin Lipkin

Nitin Telang

Gordon S Okimoto

Johann Urschitz

Mou Tuan Huang

A method for enhanced detection and statistical analysis of differentially expressed genes in gene chip microarrays employs: (a) transformation of gene expression data into an expression data matrix (image data paradigm); (b) wavelet denoising of expression data matrix values to enhance their signal-to-noise ratio; and (c) singular value decomposition (SVD) of the wavelet-denoised expression data matrix to concentrate most of the gene expression signal in primary matrix eigenarrays to enhance the separation of true gene expression values from background noise. The transformation of gene chip data into an image data paradigm facilitates the use of powerful image data processing techniques, including a generalized logarithm (g-log) function to stabilize variance over intensity, and the WSVD combination of wavelet packet transform and denoising and SVD to clearly enhance separation of the truly changed genes from background noise. Detection performance can be assessed using a true false discovery rate (tFDR) computed for simulated gene expression data, and comparing it to estimated FDR (eFDR) rates based on permutations of the available data. Where a small number (N) of samples in a group is involved, a pair of specific WSVD algorithms are employed complementarily if N&#x3e;5 and if N&#x3c;6.

Methods for enhanced detection and analysis of differentially expressed genes using gene chip microarrays

Methods and compositions are provided for diagnosing and treating(PXE) patients and PXE carriers. Methods and compositions are based on the discovery that PXE mutations are located in the MRP6 (ABCC6) gene.

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Compositions and methods of inhibiting tumor cell growth and treating and preventing cancer are provided based on administration of an orange peel extract either alone or in combination with other phytochemicals.

Extracts of orange peel for prevention and treatment of cancer

Methods and compositions are provided for diagnosing and treating (PXE) patients and PXE carriers. Methods and compositions are based on the discovery that PXE mutations are located in the MRP6 (ABCC6) gene.

Methods for diagnosing Pseudoxanthoma elasticum

The invention relates to an assay system for screening nutraceuticals, i.e., foods or food substances that occur naturally, or that are produced during processing which are capable of modulating in a subject the expression of one or more genes associated with a disease or undesirable physical condition. The nutraceuticals identified by the screening assays can be incorporated into compositions which may be administered to a subject to treat or prevent a disease or undesirable condition, or otherwise to improve the health of the subject. The invention further provides methods for modifying the amount of nutraceuticals in raw and processed foods or food substances.

Methods of screening foods for nutraceuticals

Growing community of inventors

Honolulu, HI, United States of America

Charles D Boyd