University of California

Abbott Laboratories Corporation

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Texas Biomedical Research Institute

Charles Chiu

George J Dawson

Kevin Y Cheng

Matthew Frankel

Kelly Coller

Deanna Lee

Kenn Forberg

Michael Berg

John R Hackett, Jr

Steve Miller

Scot Federman

Samia Naccache

Erik Samayoa

Eunice Chen

Doug Stryke

Nicholas W Lerche

Karen Lisa Bales

John R Hackett

Jean Patterson

Mary Michelle Leland

Kenneth Dee Carey

Dean Ehrdman

John Hackett

Embodiments are directed to systems and methods for pathogen detection using next-generation sequencing (NGS) analysis of a sample. Embodiments may apply alignment algorithms (e.g., SNAP and/or RAPSearch alignment algorithms) to align individual sequence reads from a sample in a next-generation sequencing (NGS) dataset against reference genome entries in a classified reference genome database. Embodiments of the present invention may include classifying, filtering, and displaying results to a clinician that can then quickly and easily obtain the results of the sequencing to identify a pathogen or other genetic material in a sample that is being tested. A negative sample and a corresponding database can be used to remove contaminants from a list of candidate pathogens. Thus, embodiments are directed to a system that is configured to filter the results of a sequencing alignment and classify a sample quickly.

Pathogen detection using next generation sequencing

Provided herein are compositions, methods, and kits for detecting human2 (HPgV-2). In certain embodiments, provided herein are HPgV-2 specific nucleic acid probes and primers, and methods for detecting HPgV-2 nucleic acid. In other embodiments, provided herein are HPgV-2 immunogenic composition compositions, methods of treating a subject with immunogenic HPgV-2 peptides, and methods of detecting HPgV-2 subject antibodies in a sample.

Compositions and methods for detecting human pegivirus 2 (HPgV-2)

Provided is a Titi Monkey Adenovirus (TMAdV) that can infect both human and non-human primates. Further provided are nucleic acid sequences, proteins, expression vectors and host cells, anti-TMAdV antibodies, vaccines, compositions, methods of detecting TMAdV, methods for assaying for anti-TMAdV compounds, and methods for treating or preventing a TMAdV infection.

Adenovirus isolated from titi monkeys

Provided herein are compositions, methods, and kits for detecting human Pegivirus 2 (HPgV-2). In certain embodiments, provided herein are HPgV-2 specific nucleic acid probes and primers, and methods for detecting HPgV-2 nucleic acid. In other embodiments, provided herein are HPgV-2 immunogenic composition compositions, methods of treating a subject with immunogenic HPgV-2 peptides, and methods of detecting HPgV-2 subject antibodies in a sample.

Compositions and methods for detecting human Pegivirus 2 (HPgV-2)

Adenovirus isolated from Titi Monkeys

Baboon Adenovirus (BaAdV)-2/4 and BaAdV-3 are described herein. BaAdV-2/4 and BaAdV-3 polynucleotide, polypeptides and antibodies that specifically bind BaAdV-2/4 and/or BaAdV-3 are described. Methods are described for detecting BaAdV-2/4 and BaAdV-3. Methods are also described for treating, preventing, and inducing an immune response to BaAdV-2/4 and/or BaAdV-3. Kits are also provided.

Adenoviruses and their use

Growing community of inventors

San Francisco, CA, United States of America

Charles Chiu