Wyeth

Zealand Pharma A/s

Charles Chao Wu

Panolil C Raveendranath

Jianxin Ren

Lalitha Krishnan

Mahmoud Mirmehrabi

Subodh S Deshmukh

John Leo Considine

Maotang X Zhou

Karen Sutherland

Asaf Ragim Alimardanov

Jason Brazzillo

Ting-Zhong Wang

Christoph Martin Dehnhardt

Bogdan Kazimierz Wilk

Sreenivasulu Megati

Ronald Stanley Michalak

Yanzhong Wu

Zhixian Ding

Xinxu Shi

Haris Durutlic

Yangzhong Wu

Provided are methods for the preparation of certain substituted pyrrolidine compounds, forms of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride, and methods for preparing and using these forms.

Synthesis of pyrrolidine compounds

Processes for preparing oxindoles, which can be utilized in the preparation of a variety of useful compounds, and methods for minimizing or preventing N-alkylation of amide containing compounds, including oxindoles, are provided. Also provided is a compound of the following structure: 

Process for the synthesis of progesterone receptor modulators

A process for making the compound of formula (I) wherein Ac represents acetate; X represents O or CH; Y represents C-Calkyl; and Z is selected from the group consisting of H, halogen, CN, CHO, CF, OCF, OH, C-Calkyl, C-Calkoxy, C-Cthioalkyl, NH, N(C-Calkyl), NH(C-Calkyl), NC(O)&#x2014;(CCalkyl), and NO. In his process, a compound of formula (II) is reacted with hydrazine to form a primary alkylamine, and then the primary alkylamine is reacted with acetic anhydride, to produce the compound of formula (I).

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Charles Chao Wu