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Institut National De La Sante Et De La Recherche Medicale

Institut Pasteur

Institut Pasteur and Centre National De La Recherche Scientifique

Association Pour Le D&eacute;veloppement De La Bioth&eacute;rapie Exp&eacute;rimentale Et Appliqu&eacute;e

Charles Chany

Pierre Tiollais

Christine Pourcel

Anne Louise

Marie-Francedillaoise Dubois

Marie-Francoise Dubois

Pan Hong Jiang

Aboubacar Kaba

Helmut Ankel

Italina Cerutti

Brigitte Galliot

Francoise Chany-Fournier

Marie-Josephe Chevalier

The invention relates to nucleotide sequences capable of coding for polypeptides having lectinic properties and to corresponding polypeptides of the sarcolectin type and their uses in therapeutics. In particular, the invention relates to the use of polypeptides of the sarcolection type to stimulate immunity, if necessary in combination with interferon or butyroids. The use of specific inhibitors or antagonist peptides allows opposition to the constituent production of SCL. The antibodies directed against said peptides can be used in diagnostics and therapeutics.

Compounds having lectinic properties and their biological applications

Method for the production of antigens vaccinating against the virus of B viral hepatitis. It consists of transforming a cell culture with a vector, more particularly a plasmid, itself containing an insertion sequence including itself at least the part of the viral DNA coding for the immunogen protein, capable of inducing in vivo antibody production active with respect to the whole virus, as well as the viral promoter under the control of which the transcription and translation of the above-said part of viral DNA is normally carried out, in particular in a host infected with the corresponding virus.

Method for the transformation of cells, particularly eukaryotes by a DNA

A pharmaceutical product consists of interferon which has been rendered insoluble by being coupled to a support, such as sepharose.

Pharmaceutical formulation of interferon insolubilized by fixation on a

Growing community of inventors

Paris, France

Charles Chany