University of North Carolina at Chapel Hill

Androscience Corporation

University of Rochester

Allianz Pharmascience Ltd.

Charles C-y Shih

Hui-Kang Wang

Kuo-Hsiung Lee

Chawnshang Chang

Junko Ishida

Hideji Itokawa

Ching-Yuan Su

Li Lin

Hironori Ohtsu

Qian Shi

Toshio Kitamura

Toshiyuki Kawashima

Hironari Ohtsu

A method of treating cancer, inflammatory disease, and autoimmune disease by administering to a subject in need thereof an effective amount of one or more 1,5-dipenylpenta-1,4-dien-3-one compounds. The compounds feature either or both of the phenyl rings being substituted with hydroxyl, diethyl(2-alkoxyethyl)amine, 1-(2-alkoxyethyl)piperidine, sulfonate, phosphinate, or phosphate.

Treatment of cancer, inflammatory disease, and autoimmune disease

This invention relates to compounds of Formula (I), (II), or (III) as shown in the specification, which contain a 1,5-diphenylpenta-1,4-dien-3-one backbone. These compounds can be used to treat cancer, inflammatory disease, or autoimmune disease.

1,5-diphenyl-penta-1,4-dien-3-one compounds

The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.

Curcumin analogues and uses thereof

Growing community of inventors

Solana Beach, CA, United States of America

Charles C-y Shih