Viro Chem Pharma, Inc.

Cytovia, Inc.

Charles Blais

Laval Chan Chun Kong

Louis Vaillancourt

Christophe Moinet

Marc Courchesne

Monica Bubenik

Sui Xiong Cai

John A Drewe

Shailaja Kasibhatla

Oswy Z Pereira

Constantin G Yannopoulos

Ben Y Tseng

Henriette Gourdeau

Denis Labrecque

Réal Denis

William D Kemnitzer

Compounds according to formula (I): wherein R, R, R, n and X are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity. Additionally, compounds according to Formula III: wherein Z, R', and R&#x2032;are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful as intermediates for production of compounds that modulate CCR5 chemokine receptor activity.

Spirotropane compounds

The present invention is directed to a substituted 4H-chromene represented by the Formula 1R, substantially free from the corresponding (S)-stereoisomer: The present invention also relates to the discovery that compound 1R, substantially free from the corresponding (S)-stereoisomer, is an activator of caspases and inducer of apoptosis, as well as an antivascular agent. Therefore, compound 1R, substantially free from the corresponding (S)-stereoisomer, can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs. Compound 1R, substantially free from the corresponding (S)-stereoisomer, also can be used for the treatment of diseases due to overgrowth of vasculature, such as solid tumors and ocular neovascularization.

Substituted 4-aryl-chromene as activator of caspases and inducer of apoptosis and as antivascular agent and the use thereof

Compounds according to formula (I): wherein A, R, Rand Rare defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.

Spirotropane compounds and methods for the modulation of chemokine receptor activity

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Beaconsfield, Canada

Charles Blais