Warner Lambert LLC

Warner-lambert Company

Charles Andrianjara

Bernard Gaudilliere

Francine Breuzard

Patrick Bernardelli

Henri Jacobelli

Fabrice Vergne

Pierre Ducrot

Remi Lavalette

Edwige Lorth Ois

The invention provides 1,3,4-thiadiazoles and 1,3,4-oxadiazoles having the following Formula I:in which,

Thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors

A compound selected from those of formula (I):in which:

Triazolo compounds as MMP inhibitors

The present invention relates to triazolo&lsqb;4,3-a&rsqb;quinazoline-5-ones and 5-thiones of Formula I and Formula II, whereby I and II are position isomers of group R on nitrogen 3 or 4. Optionally, the invention also relates to the racemic forms, isomers and pharmaceutically acceptable salts thereof. The invention further relates to a method for the production thereof and to compositions containing said derivatives. The compounds act as inhibitors of phosphodiesterase IV (PDE-4) and, as such, have utility in treating asthma, chronic bronchitis, acutte pulmonary attack, atopic dermatitis, pulmonary hypertension, pulmonary insufficiency, cardiac insufficiency, psoriasis, inflammatory conditions of the digestive system such as haemorrhagic rectocolitis and Crohn's disease, acute respiratory distress syndrome, acute pancreatitis, benign hypertrophy of the prostate, rheumatoid arthritis, multiple sclerosis, depression, ischaemia-induced neuronal damage, partial cerebral ischaemia, and cancer such as malignant tumor and chronic lymphoid leukemia.

1-Amino triazoloc4,3-a&excl; quinazoline-5-ones and/or -5-thiones inhibiting phosphodiesterase IV

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Fresnes, France

Charles Andrianjara