Millennium Pharmaceuticals Limited

Charles A Minor

Shomir Ghosh

Tracy J Jenkins

Bing Guan

Mingshi Dai

Gang Li

Douglas F Burdi

Robert A Bennett

The present invention provides compounds of general formula I:  or a pharmaceutically acceptable salt thereof, wherein R, X, Z, R, X, Ar, n, Rand Rare defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.

Aryl sulfonamides useful as inhibitors of chemokine receptor activity

The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein R, X, Z, R, X, Ar, n, Rand Rare defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.

Disclosed are CCR8 inhibitors represented by Structural Formulas (I):  The variables in Structural Formula (I) are described herein. Also disclosed are methods of treating a subject with a CCR8 mediated condition, especially asthma, by administering one of the disclosed CCR8 inhibitors to the subject.

CCR8 inhibitors

Disclosed is an inhibitor of CCR8 that is represented by Structural Formula (I):  Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent and a CCR8 inhibitor represented by Structural Formula (I). Also disclosed is a method of treating inflammatory disorders in a subject by administering a CCR8 inhibitor to the subject.

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Kingston, MA, United States of America

Charles A Minor