Human Genome Sciences, Inc.

Atherogenics, Inc.

Charles A Kunsch

Craig A Rosen

Gil H Choi

Steven C Barash

Michael R Fannon

Patrick J Dillon

Brian A Dougherty

Arvind Chopra

Camella Bailey

Alex Hromockyj

Signe Erickson Varner

Jayraz Luchoomun

Xilin Chen

Patrick J Dillion

Patrick S Dillon

Gil A Choi

Joerg Peter Oettgen

Towia Aron Libermann

L Sydnor Johnson

Brian Dougherty

The present invention provides polynucleotide sequences of the genome of, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

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This invention is in the area of regulatory DNA sequences and their methods of use. Specifically, DNA sequences found in the regulatory region of cytoprotective genes are described that are termed cytoprotective response elements. DNA constructs also are provided that include cytoprotective response elements operably linked to heterologous protein coding sequence, as well as cells and non-human organisms that include the cytoprotective response elements optionally operably linked to a heterologous protein coding sequence, and a method for screening for a compound that increases mRNA or protein regulated by a cytoprotective response element. It has been discovered that the cytoprotective response elements mediate the coordinate activation of certain genes that protect cells from damaging effects of oxidative stress, and that they do so, for example during conditions of hemodynamic shear stress.

Protection against oxidative stress and inflammation by a cytoprotective response element

The present invention relates to novel vaccines for the prevention or attenuation of infection byThe invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides ofAntigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.

Streptococcus pneumoniae SP036 polynucleotides, polypeptides, antigens and vaccines

The present invention relates to novel antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3). BTG-2 and BTG-3 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same.

Diagnostic methods based on human BTG-2 and BTG-3 polypeptides

The present invention relates to novel vaccines for the prevention or attenuation of infection byThe invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides ofAntigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detectingnucleic acids, polypeptides and antibodies in a biological sample.

Streptococcus pneumoniae SP042 polynucleotides

The present invention relates to novel genes fromand the polypeptides they encode. Also provided as are vectors, host cells, antibodies and methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists ofpolypeptide activity. The invention additionally relates to diagnostic methods for detectingnucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Enterococcus.

Enterococcus faecalis polynucleotides encoding EF059

The present invention relates to novel vaccines for the prevention or attenuation of infection by. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detectingnucleic acids, polypeptides and antibodies in a biological sample.

Streptococcus pneumoniae SP036 polynucleotides

The present invention provides polynucleotide sequences of the genome of , polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

Staphylococcus aureus polynucleotides and sequences

The present invention relates to antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3). BTG-2 and BTG-3 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies to BTG-2 and BGT-3.

Human B-cell translocation genes-2 and 3 antibodies

The present invention relates to novel vaccines for the prevention or attenuation of infection by . The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of . Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.

Streptococcus pneumoniae antigens and vaccines

The present invention relates to a novel gene from EF040, and the encoded polypeptides. Also provided are vectors, host cells, antibodies and methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of EF040 polypeptide activity. The invention additionally relates to diagnostic methods for detecting Enterococcus EF040 nucleic acids, encoded polypeptides and anti-EF040 antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Enterococcus.

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Norcross, GA, United States of America

Charles A Kunsch