Bsi Corporation

Charles A Hastings

Dale G Swan

A method of preparing (e.g., priming) a surface for attachment of a target molecule to the surface. The method provides a multifunctional reagent having multiple photoreactive groups. The groups can be activated in order to covalently bind one or more of them to the surface in such a manner that one or more will remain unbound. The unbound groups are then capable of reverting to their activatable state, whereupon they can again be activated in order to bind a target molecule having abstractable hydrogen atoms.

Restrained multifunctional reagent for surface modification

A multifunctional reagent is provided that is useful for the attachment of desired molecules to support surfaces. A reactive reagent molecule of the invention is 'restrained' in that it is conformationally and/or chemically restricted from reacting with either itself or with other molecules of the same reagent. Upon activation, this feature causes the attachment of less than all of the reactive sites of the multifunctional reagent to a surface, thereby leaving the remaining sites free to react with molecules desired to be immobilized onto the surface.

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Hopkins, MN, United States of America

Charles A Hastings