University of Pittsburgh

The United States Government As Represented by the Department of Veterans Affairs

Charleen T Chu

Beibei Chen

Rama K Mallampalli

Yuan Liu

A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II:

Chemical inhibition of the E3 ligase subunit FBXO7 confers neuroprotection and anti-inflammatory activity by stabilizing mitochondria

A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II: wherein each of R-Ris independently H, halogen, optionally-substituted alkyl, amino, alkoxy or hydroxy;

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Wexford, PA, United States of America

Charleen T Chu