University of Washington

Phaserx, Inc.

Genevant Sciences Gmbh

Charbel Diab

Mary Gallagher Prieve

Allan Sachs Hoffman

Patrick S Stayton

Anna S Gall

Paul Hickok Johnson

Priyadarsi De

Robert W Overell

Sean D Monahan

Michael S DeClue

Craig L Duvall

Anthony Convertine

Danielle Benoit

Amber E Paschal

Amber E E Paschal

Pierrot Harvie

Maher Qabar

Anna Galperin

Debashish Roy

Russell N Johnson

Michael E Houston, Jr

Michael E Houston

Amber Ee Paschal

Anthony J Convertine

Paul Johnson

Robert Overell

Paul H Johnson

Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

Block copolymers

Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.

Micellic assemblies

Nucleic acid constructs and methods of using the same

Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.

Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof.

Multiblock copolymers

Provided herein are monomers incorporating folate or other targeting agent, polymers prepared therefrom, polymers prepared therefrom having a therapeutic agent covalently coupled thereto, as well as micelles and therapeutic compositions thereof.

Targeting monomers and polymers having targeting blocks

Compositions comprising a heterogeneous polymeric micelle and an agent (e.g., a polynucleotide) associated with the micelle are disclosed, together with methods for intracellular delivery of such agent.

Heterogeneous polymeric micelles for intracellular delivery

Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.

Polymeric carrier

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Seattle, WA, United States of America

Charbel Diab