Orthovita, Inc.

Zimmer Knee Creations, Inc.

Prosidyan, Inc.

Titan Spine, LLC

Mo-sci Corporation

Vita Special Purpose Corporation

Vita Licensing, Inc.

Zimmer Spine, Inc.

Stryker Spine

Sulzer Spine-tech Inc.

Charanpreet S Bagga

Erik M Erbe

Hyun W Bae

James Philip Murphy

Peter F Sharkey

Charles F Leinberry

Antony Koblish

Steven B Cohen

Theodore D Clineff

Gina M Nagvajara

Peter F Ullrich, Jr

Thomas E Day

Steve B Jung

Shaun B Hanson

Steven B Jung

Michael W Paris

Gregory J Pomrink

James M Freid

Marissa M Darmoc

Maarten Persenaire

Christopher D Mandeen

Jeffrey G Marx

Marissa M Conrad

Michael J Simpson

Robert J Chiasera, Jr

David A Hanson

Stephen G Gilbert

Eric L Gray

Carlo Ventre

Dale L Brady

Dean A Entrekin

Bradford S Tucker

Harvinder Sandhu

Michael E Doran

Steven B Brown

Peter F Ullrich

Michael E Doran Doran

Hyun Bae

James P Murphy

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.

Wound care device having dynamic bioactive nanofiber scaffolding

Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.

Bioactive porous bone graft implants

Dynamic bioactive nanofiber scaffolding

The present disclosure relates to a dynamic bioactive bone graft material having an engineered porosity. In one embodiment, a bone graft material is provided having bioactive glass fibers arranged in a porous matrix that is moldable into a desired shape for implantation. The material can be substantially without additives and can include at least one nanofiber. The porous matrix may include a combination of one or more pore sizes including nanopores, macropores, mesopores, and micropores. In another embodiment, a bone graft implant is provided having a matrix comprising a plurality of overlapping and interlocking bioactive glass fibers, and having a distributed porosity based on a range of pores provided in the bioactive glass fibers. The distributed porosity can comprise a combination of macropores, mesopores, and micropores, and the matrix can be formable into a desired shape for implantation into a patient.

Dynamic bioactive bone graft material having an engineered porosity

The embodiments provide provides devices, instruments, and associated methods for treating joint pain. A joint is evaluated using magnetic resonance imaging to detect any defects in the subchondral bone. For example, using T2-weighted MRI images, bone marrow lesions or edemas can be identified, and using T1-weighted MRI images, associated regions of sclerotic bone adjacent to the bone marrow lesion can be identified. The treatment method may involve introducing a bone void filler material at the site to address the bone marrow lesion or edema, and/or drilling and inserting an implant to address the sclerotic bone, bone marrow lesion or edema, and insufficiency or stress fractures. An access path is mapped to a location in the subchondral region where the insufficiency fracture resides. The access path attempts to preserve an articular surface of the joint. A reinforcing member that stabilizes the insufficiency fracture is then implanted via the access path.

Method for treating joint pain and associated instruments

Bioactive porous bone graft implants in various forms suitable for use in bone tissue regeneration and/or repair, as well as methods of use are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may be contained in polymer for enhanced clinical results and better handling.

Bioactive porous bone graft compositions with collagen

Synthetic, bioactive ultra-porous bone graft materials having an engineered porosity, and implants formed from such materials are provided. In particular, these implants comprise bioactive glass and incorporate allograft material for osteoinduction. The implants are suitable for bone tissue regeneration and/or repair.

Bone graft implants containing allograft

Disclosed is directed to a method for restoring bone in an animal comprising: accessing a site to be restored; loading a syringe body with a flowable bone graft material; mating the syringe body with a delivery tube; positioning the delivery tube at the site to be restored; using a syringe piston to advance the said material into the delivery tube; using the syringe piston or a plunger that mates with the delivery tube after removal of the syringe body to deliver the bone graft to the site at a force of less than 50 lbs. extrusion force; wherein said material is at least 75% porous with a mineral to polymer ratio of 80:20.

Method for restoring bone using shapeable bone graft substitute and instruments for delivery thereof

Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.

Bioactive load-bearing composites

Methods of providing dose controlled application of bone graft materials are disclosed. In particular, methods for determining a target quantity of bone graft material for clinical application in order to ensure maximum clinical results are provided. These methods comprise determining the target weight of the material to be applied.

Method of dose controlled application of bone graft materials by weight

Growing community of inventors

Basking Ridge, NJ, United States of America

Charanpreet S Bagga