University of Memphis Research Foundation

Chaoxi Wu

Joel D Bumgardner

Hengjie Su

Daniel G Abebe

Kwei-Yu Liu

Tomoko Fujiwara

Gregory McGraw

Carlos Lee Bumgardner

The invention includes chitosan nanofibers having enhanced structural integrity, compositions comprising such chitosan nanofibers, and related methods of use. In a particular aspect, electrospun chitosan nanofibers can be reversibly acylated to enhance structural integrity and promote healing and the formation of tissues in a subject. In another aspect, electrospun chitosan nanofibers comprising at least a portion of the amino groups protected, such as through N-tert-butoxycarbonyl groups, demonstrate enhanced structural integrity and promote healing and the formation of tissues in a subject. The invention also includes compositions and methods for producing a modified chitosan material having anti-inflammatory and pro-healing characteristics and methods of using the modified chitosan materials in a film, a gel, a membrane, microfibers, nanofibers, nano- or micro-particles/spheres and/or sponges. In some aspects, microspheres and methods of producing microspheres comprising modified chitosan are included.

Chitosan nanofiber compositions, compositions comprising modified chitosan, and methods of use

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Memphis, TN, United States of America

Chaoxi Wu