Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Chaolei Wang

Jingyi Wang

Lichun Wang

Jiaqiang Cai

Yongyong Wu

Qiang Tian

Shuai Song

Mingliang Zhao

Guangchao Zhang

Shuangshuang Duan

Provided are tetrahydroisoquinoline derivatives, the preparation and use thereof. More specifically, provided are the tetrahydroisoquinoline derivatives or a pharmaceutically acceptable salt, ester, stereoisomer, tautomer, polymorph, solvate, isotopically labeled compound, metabolite or prodrug thereof. Further provided are a preparation process of the compound, the intermediates, a pharmaceutical composition comprising the compound and the use thereof in the treatment or prevention of a thromboembolic disorder.

Tetrahydroisoquinoline derivatives, preparation process and use thereof

Related is a nitrogen-containing benzoheterocycle compound containing a carboxylic acid group as shown in general formula (I), or a stereoisomer or pharmaceutically acceptable salt thereof. The compound has excellent pharmacokinetic properties and extremely remarkable liver targeting properties, and a pharmaceutical composition comprising the same may be used as a CCR antagonist, in particular a CCR2 and/or CCR5 antagonist and can be used in mediated disease, including, but not limited to, nonalcoholic fatty liver disease (NAFLD) or the like. 

Nitrogen-containing benzoheterocycle compound comprising carboxylic acid group, preparation method and use thereof

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Sichuan, China

Chaolei Wang