Guangdong Raynovent Biotech Co., Ltd.

Guangdong Zhongsheng Pharmaceutical Co., Ltd

Other

Guangdong Xianqiang Pharmaceutical Co., Ltd

Chaofeng Long

Xiaoxin Chen

Zhuowei Liu

Shuhui Chen

Jian Li

Cheng Xie

Xing Liu

Peng Zhang

Peng Li

Fang Liu

Kevin X Chen

Lingyun Wu

Jian Xiong

Zhengxia Chen

Jingjing Wang

Xuanjia Peng

Zhiqiang Liu

Lijuan Chen

Guoping Hu

Meibi Dai

Chengwu Liu

Yan Wang

Li Zhang

Hao Wu

Xiao Xun Zhang

Haiying He

Zheng Wang

Zhigan Jiang

Jun Lin

Changqing Wei

Zhen Gong

Zhifei Fu

Guibai Liang

Zhengwei Li

Jian Wei Li

Yikai Wang

Haixia Zhao

Zhiliang Yuan

Yunhui Li

Jiajun Huang

Guangqiang Zhou

Zhiwei Cheng

Zhenyou Tan

Chenshi Xie

Xiao Zhang

Yang Zhang

Leilei Gao

Haoyu Ye

Linyun Wu

The present invention discloses a class of anti-influenza virus compounds, and the use thereof in the preparation of a drug for treating diseases associated with influenza viruses. In particular, the present invention discloses a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

Anti-influenza virus pyrimidine derivatives

Disclosed are sodium salts of pyrimidine derivatives, and a series of crystal forms thereof. The series of crystal forms exhibit a good druggability, such as stability, fluidity, compressibility, etc., and provide a variety of options of APIs for subsequent drug product development.

Dominant salt forms of pyrimidine derivatives, and crystal forms thereof

Anti-influenza virus pyrimidine derivative

Disclosed are a crystal form and a salt form of a pyrazolopridine compound, and a preparation method therefor. Further included is the use of the crystal form in preparing anti-influenza virus drugs.

Crystal form and salt form of pyridoimidazole compound and preparation method therefor

The present invention provides a salt form, a crystal form, and a preparation method of a compound as an FGFR4 inhibitor and medical uses thereof. 

Salt form and crystal form of compound as FGFR4 inhibitor and preparation method thereof

Hydroxyl purine compounds represented by formula (I), tautomers or pharmaceutically acceptable salts thereof, and applications thereof as PDE2 or TNF-&#x3b1; inhibitors.

Hydroxyl purine compounds and applications thereof

The present invention discloses a class of anti-influenza virus compounds, and the use thereof in the preparation of a drug for treating diseases associated with influenza viruses. In particular, the present invention discloses a compound represented by formula (I) and a pharmaceutically acceptable salt thereof. 

Provided are a class of compounds as shown in formula (I) as FGFR4 inhibitors, and pharmaceutically acceptable salts thereof, preparation methods therefor and the use thereof in the preparation of drugs for treating FGFR4-related diseases. 

FGFR4 inhibitor and preparation method and use thereof

Disclosed are a crystal form and a salt form of and a preparation method for a tyrosine kinase inhibitor. 

Crystal form and salt form of and preparation method for tyrosine kinase inhibitor

The present invention relates to a tyrosine kinase inhibitor and a pharmaceutical composition comprising same. The tyrosine kinase inhibitor of the present invention has the structures as shown in the following formula (I) or (II): 

Tyrosine kinase inhibitor and pharmaceutical composition comprising same

Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNF&#x3b1; inhibitors, in particular, the compounds as shown in formula (I), or tautomers or pharmaceutically acceptable salts thereof. 

Hydroxyl purine compounds and use thereof

A compound represented by Formula I or pharmaceutically acceptable salt thereof. The present invention relates to a 4-arylamino quinazoline hydroxamic acid compound having a histone deacetylase inhibitory activity, preparation method of the compound, pharmaceutical composition comprising the compound, and use of the compound and the pharmaceutical composition in the preparation of a histone deacetylase inhibitor medicine. The present invention aims at acquiring, via a medicine design and a synthetic technology, a series of selective histone deacetylase inhibitors having good hypotype selectivity and favorable pharmacokinetic characteristics based on optimization of an enzyme surface recognition region and connection region of 4-arylamino quinazoline, thus reducing an effect on normal tissues or cells while improving an antineoplastic activity of the normal tissues or cells.  In Formula I, the variables are as described herein.

Histone deacetylase inhibitor, and preparation method and use thereof

The present invention discloses a class of pyrrolidine derivatives as PPAR agonist, and their use for the treatment of some diseases of PPAR receptor-associated pathways (such as nonalcoholic steatohepatitis and concurrent fibrosis, insulin resistance, primary biliary cholangitis, dyslipidemia, hyperlipidemia, hypercholesterolemia, atherosclerosis, hypertriglyceridemia, cardiovascular disease, obesity or the like). In particular, the present invention discloses a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof. 

Pyrrolidine derivatives as PPAR agonists

The invention discloses a crystal form A of a compound (I) and a preparation method thereof, and further discloses an application of the crystal form A as a PDE2 or TNF-&#x3b1; inhibitor. 

Crystal form A of 7-(cyclopropylmethyl)-1-((()-4-hydroxy-4-methylcyclohexyl)methyl)-3-methyl-1H-purine-2,6-(3H,7H)-dione for treating liver diseases

Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNF&#x3b1; inhibitors, in particular, the compounds as shown in formula (I), or tautomers thereof or pharmaceutically acceptable salts thereof. 

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Guangdong, China

Chaofeng Long