Cccc First Harbor Engineering Co., Ltd.

No. 2 Engineering Co. of Cccc First Harbor Engineering Co., Ltd.

Tianjin Weijie Pharmaceutical Co., Ltd

Guangdong Laboratory of Artificial Intelligence and Digital Economy (sz)

No.2 Engineering Company Ltd. of Cccc First Harbor Engineering Company Ltd

Chao Zhang

Qiang Wang

Yiyong Li

Naishou Zhang

Honghai Song

Chuang Du

Zhicun Sun

Zhenjie Tao

Yipin Cheng

Xuhong Suo

Zhanwei Han

Bo Yu

Yongshuai Zhu

Jinjin Ning

Haiping Huang

Yunliang Li

Zexu Guan

Xiao Chen

Yuanzheng Yue

The present application relates to an installation method for a closure joint of an immersed tunnel, and belongs to the technical field of closure joints; the installation method comprises the steps: establishing a first coordinate system; distributing feature points; installing the Ntube coupling; installing an Ntube coupling and pushing out a push-out segment; wherein, the first coordinate system is established at a tail end of an Ntube coupling, breakthrough points NS and NW are distributed at a head end and a tail end of a Ntube coupling respectively, breakthrough points DS and DW are distributed at a push-out segment, and breakthrough points NS and NW are distributed at a head end and a tail end of a Ntube coupling respectively; and coordinates of the breakthrough points DS, DW, NS, NW, NS, NW in the first coordinate system are calculated respectively; the installation method can improve the installation accuracy of the closure joint and is easy to operate.

Installation method for closure joint of immersed tunnel

The present invention discloses a preparation method of 2,3-dimethyl phenyl-1-trityl-imidazole-4-ketone. In accordance with this method, imidazole-4-ethyl formate is used as a raw material; ethyl formate is used for amino protection, 1-trityl-1H-imidazole-4-formic acid is obtained after basic hydrolysis; 1-trityl-1H-imidazole-4-formic acid and N,O-dimethylhydroxylamine hydrochloride are subjected to condensation so as to obtain N-methoxyl-N-methyl-1-trityl-1H-imidazole-4-formamide; and N-methoxyl-N-methyl-1-trityl-1H-imidazole-4-formamide and a Grignard reagent prepared by the reaction of 2,3-dimethylbromobenzene with magnesium are subjected to a Grignard reaction, and then the target product 2,3-dimethyl phenyl-1-trityl-1H-imidazole-4-ketone is obtained. Compared with the reported preparation methods, the preparation method is more convenient to operate and is beneficial for industrial production.

Preparation method of dexmedetomidine intermediate

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Tianjin, China

Chao Zhang