Chemocentryx, Inc.

Ppg Industries Ohio, Inc.

Chao Yu

Penglie Zhang

Ju Yang

Manmohan Reddy Leleti

Hiroko Tanaka

Dean R Dragoli

Xi Chen

Rajinder Paul Singh

Venkat Reddy Mali

Viengkham Malathong

Jaroslaw Kalisiak

Junfa Fan

Jeffrey P McMahon

Antoni Krasinski

Yu Jiao

Jay Patrick Powers

Pingchen Fan

Rebecca M Lui

Dennis D Warren

John E DeAngelis

Russell Willis Schrier

James J Campbell

Karen Ebsworth

Joseph Medzius

James Franklin Priddy

Jeffrey P McMAHON

Robert M Bonaddio

Jeffrey Mcmahon

Joseph G Koepfinger

Hiroko Tankaka

Russell W Schrier

Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.

2-oxindole compounds

Compounds are provided as inhibitors of CXCR2, having the structure:

Inhibitors of CXCR2

Compounds are provided as chemokine inhibitors having the structure:

Modulators of chemokine receptors

The present disclosure provides, inter alia, methods of treating generalized pustular psoriasis (GPP) by administering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C-X-C motif chemokine receptor 2 (CXCR2) antagonist. Also provided herein are methods of modulating dysregulated IL-36 signaling in a subject in need thereof and methods of reducing neutrophil, inflammatory dendritic cell (iDC), and/or CD4 T cell accumulation in a subject in need thereof, said methods, include dministering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C-X-C motif chemokine receptor 2 (CXCR2) antagonist. In some embodiments, the CCR6 and/or CXCR2 antagonist has the formula:

Methods of treating generalized pustular psoriasis with an antagonist of CCR6 or CXCR2

Methods and systems are provided for automated shaping of a glass sheet. The methods comprise preheating the glass, bending the glass through selective, and focused beam heating through the use of an ultra-high frequency, high-power electromagnetic wave, and computer implemented processes utilizing thermal and shape (positional) data obtained in real-time, and cooling the glass sheet to produce a glass sheet suitable for use in air and space vehicles.

Microwave heating glass bending process

The present disclosure provides, inter alia, methods of treating generalized pustular psoriasis (GPP) by administering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C&#x2014;X&#x2014;C motif chemokine receptor 2 (CXCR2) antagonist. Also provided herein are methods of modulating dysregulated IL-36 signaling in a subject in need thereof and methods of reducing neutrophil, inflammatory dendritic cell (iDC), and/or CD4 T cell accumulation in a subject in need thereof, said methods, include administering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C&#x2014;X&#x2014;C motif chemokine receptor 2 (CXCR2) antagonist. In some embodiments, the CCR6 and/or CXCR2 antagonist has the formula: 

Compounds are provided as inhibitors of CXCR2, having the structure: 

Compounds are provided as chemokine inhibitors having the structure: 

A glass sheet used in the making of an aircraft windshield is shaped using the 'cut-to-size' method instead of the 'out-after-bend' method. In a preferred aspect of the invention the 'cut-to-size' method is practiced using a bending iron having a sheet shaping rail having a stationary shaping rail portion mounted on a support member and an articulating shaping rail portion pivotally mounted on the support member for movement from a non-shaping position to a shaping position.

Bending device for shaping glass for use in aircraft transparencies

Growing community of inventors

Sunnyvale, CA, United States of America

Chao Yu