Other

Sandia Corporation

Chao Yan

Richard Neil Zare

David J Rakestraw

Deon Stafford Anex

Rajeev Dadoo

The present invention is a separation-detection device, which comprises high-voltage power supply, capillary chromatographic column and detection equipment. In addition, the present invention employs high-pressure pump. The device can apply pressure forward, backward or bi-directionally on the capillary column and rinse the column forward or backward with the high-pressure pump. Thus not only avoid bubble formation and current breakdown in column but also guarantee the high efficiency. It can run in several modes by changing different chromatographic columns.

Multiuse pressure electric chromatographic device

Method and apparatus for controlling precisely the composition and delivery of liquid at sub-.mu.L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-.mu.L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column.

Electro-osmotically driven liquid delivery method and apparatus

Capillary columns are packed using electroosmotic flow (EOF) induced by an electrical double layer on the internal wall of a fused silica capillary and the electrophoretic mobility of positively-charged or negatively-charged particles of packing material. Electrokinetic packing is also applicable to uncharged packing particles. With this electrokinetic method several capillaries can be packed simultaneously. Electrokinetically packed capillary columns are useful for the separation of test mixtures and of pharmaceuticals in both electrochromatography and micro-HPLC.

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Pleasanton, CA, United States of America

Chao Yan