Massachusetts Institute of Technology

The Johns Hopkins University

The Brigham and Women's Hospital, Inc.

The Broad Institute, Inc.

Other

University of California

University of Texas System

Harvard College

University System of Maryland

Ion Geophysical Corporation

Chao Wang

Aviv Regev

Vijay K Kuchroo

Pengfei Xie

Hongkun Park

Le Cong

Ana Carrizosa Anderson

Jellert Gaublomme

Meromit Singer

Charles Young

Karthik Shekhar

Nir Yosef

Kellogg Schwab

Howard David Yingst

Youjin Lee

Liangbing Hu

Alexander K Shalek

Ju Li

Stephen R Adams

Yonggang Yao

Akihiro Kushima

Eric T Ahrens

Junjie Niu

James Kaminski

Tiancheng Pu

Michael Manto

Majid Minary-Jolandan

Mohammadreza Mahmoudi

Scott R Burlison

Salvador Moreno

A highly active and selective solid catalyst comprising stable single-atom iridium (Ir) anchored in a zeolite, e.g., ZSM-5, for upcycling of plastics, such as high-density polyethylene, to yield valuable lower molecular weight hydrocarbon products is disclosed.

Efficient and selective conversion of high-density polyethylene into valuable hydrocarbons

This disclosure provides compositions of SALTAME core containing compounds and associated methods for use in tracking cells by magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), and related methods.

Fluorous metal chelates compositions

A catalytic structure has a plurality of high-entropy alloy (HEA) nanoparticles. Each HEA nanoparticle is composed of a homogeneous mixture of elements of cobalt (Co), molybdenum (Mo), and at least two transition metal elements. For example, in some embodiments, each HEA nanoparticle is a quinary mixture of Co, Mo, iron (Fe), nickel (Ni), and copper (Cu). The homogeneous mixture in each HEA nanoparticle forms a single solid-solution phase. The catalytic structure is used to catalyze a chemical reaction, for example, ammonia decomposition or ammonia synthesis. Methods for forming the catalytic structure are also disclosed.

High-entropy alloy (HEA) catalysts, methods of forming HEA catalysts, and methods of using HEA catalysts

Scalable 3D-printing of ceramics includes dispensing a preceramic polymer at the tip of a moving nozzle into a gel that can reversibly switch between fluid and solid states, and subsequently thermally cross-linking the entire printed part 'at-once' while still inside the same gel. The solid gel, including mineral oil and silica nanoparticles, converts to fluid at the tip of the moving nozzle, allows the polymer solution to be dispensed, and quickly returns to a solid state to maintain the geometry of the printed polymer both during printing and the subsequent high temperature (160° C.) cross-linking. The cross-linked part is retrieved from the gel and converted to ceramic by high temperature pyrolysis. This scalable process opens new opportunities for low-cost, high-speed production of complex 3-dimensional ceramic parts, and will be widely used for high temperature and corrosive environment applications, including electronics and sensors, microelectromechanical systems, energy, and structural applications.

Additive manufacturing of polymer ceramics

Described herein are methods for suppressing an immune response in a subject, e.g., a subject with an autoimmune disease, by administering to the subject a therapeutically effective amount of recombinant CD5L, CD5L homodimers and/or CD5L:p40 heterodimers, or nucleic acids encoding any of these. Also described are methods for enhancing an immune response in a subject, e.g., a subject with cancer, infection, or an immune deficiency, by administering to the subject a therapeutically effective amount of an antibody or antigen-binding fragment thereof that binds specifically to CD5L, D5L homodimers and/or CD5L:p40 heterodimers, and inhibits their binding to the IL-23 receptor, or inhibits formation of the CD5L homodimer and/or CD5L:p40 heterodimer, or inhibitory nucleic acids that target CD5L and/or p40.

Method of treating autoimmune disease with lymphocyte antigen CD5-like (CD5L) protein

Core-shell nanoparticles having a solid core comprising a first metal and a shell comprising a second metal disposed at least a portion of the exterior surface of the core. The core-shell nanoparticles comprise a non-precious transition metal and the second metal comprises a precious metal or semi-precious metal. The core-shell nanoparticles can be used to catalyze oxygen reduction reactions. Also provided are compositions comprising the core-shell nanoparticles, methods of making same, and devices of same.

Materials plated with precious metals and making and using same

Described are methods for converting methane to olefins, aromatics, or a combination thereof using a single atom catalyst comprising CeOnanoparticles impregnated with individual atoms of noble metals including Pt, Pd, Rh, Ru, Ag, Au, Ir, or a combination thereof. These single atom catalysts of the present invention are heated with methane to form olefins and aromatics.

Method for preparation of nanoceria supported atomic noble metal catalysts and the application of platinum single atom catalysts for direct methane conversion

This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.

T cell balance gene expression, compositions of matters and methods of use thereof

Described are methods of removing phosphorous from aqueous solutions using copper-substituted aluminosilicate materials. The copper-substituted aluminosilicate materials are copper-substituted zeolites that are recyclable and have desirable recovery efficiencies. Also described are methods of making copper-substituted aluminosilicate materials, using copper-substituted aluminosilicate materials, systems using copper-substituted aluminosilicate materials, and methods of using these systems.

Methods of removing and recovering phosphorus from aqueous solutions

The present invention provides markers, marker signatures and molecular targets that correlate with dysfunction of immune cells and are advantageously independent of the immune cell activation status. The present markers, marker signatures and molecular targets provide for new ways to evaluate and modulate immune responses. Specifically, POU2AF1 modulation is provided for use as a marker, marker signature and molecular target. Therapeutic methods are also provided to treat a patient in need thereof who would benefit from an increased immune response.

Compositions and methods for evaluating and modulating immune responses by detecting and targeting POU2AF1

The present invention provides markers, marker signatures and molecular targets that correlate with dysfunction of immune cells and are advantageously independent of the immune cell activation status. The present markers, marker signatures and molecular targets provide for new ways to evaluate and modulate immune responses. Specifically, GATA3 and/or FOXO1 modulation are provided for use as markers, marker signatures and molecular targets. Therapeutic methods are also provided to treat a patient in need thereof who would benefit from an increased immune response.

Compositions and methods for evaluating and modulating immune responses by detecting and targeting GATA3

The presently disclosed fluidic sensor system and method comprise multifunctional nanoprobe-enabled capture for early detection of chemical and/or biological pathogens in a liquid sample. This sensor system and method can be used for food and environmental monitoring.

Multifunctional nanoprobe-enabled capture and early detection of microbial pathogens

Computer systems and methods are provided for time domain reconstructed seismic wavefield imaging. The original source signal or extended source can be forward propagated based on a model of a subsurface region, in order to generate a residual by comparison to field data. The residual can be back-propagated to generate a reconstructed source signal, which can be forward propagated to generate a reconstructed source wavefield. Seismic images can be generated by cross correlating the forward-propagated reconstructed source wavefield and the back-propagated receiver wavefield. The model can include seismic parameters such as velocity, density, anisotropy and attenuation characterizing the subsurface region, and can be iteratively refined to improve image quality, based on the reconstructed source wavefield in comparison to the field data.

System and method for reconstructed wavefield imaging

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Cambridge, MA, United States of America

Chao Wang