Vertex Pharmaceuticals, Inc.

Edan Diagnostics

Abbott Point of Care Inc.

Opti Medical Systems

I-stat Corporation

Sequenom, Inc.

Agena Bioscience, Inc.

Orchid Biosciences, Inc.

Chao Lin

Paul David Swanson

Zhixiang Jason Zhao

Yi Zhou

Graham Davis

Imants R Lauks

Ann Dak-Yee Kwong

Francesco Gerald Salituro

Tiansheng Wang

Paul S Charifson

Francois Maltais

Luc J Farmer

Mark Willem Ledeboer

Emanuele Perola

Huai Gao

John J Court

Upul Keerthi Bandarage

Hongbo Deng

Randy Scott Bethiel

John P Duffy

Brian Ledford

Wenxin Gu

Joseph M Kennedy

Michael P Clark

Ioana Davies

M Woods Wannamaker

Dylan H Jacobs

Ursula A Germann

Min Jiang

Steven Jones

Cary James Miller

Randal Byrn

Joseph L Kim

Huarui He

Kurt A Morgenstern

Ann Kwong

Tara Lynn Kieffer

Paul Heaney

David Opalsky

Andrzej Maczuszenko

Raymond J Pierce

John Allan Thomson

Kai Lin

Paul R Caron

Ted Fox

Phillip Bruce, Iii

Charles Griswold

Sheila A Walker

Christoph Sarrazin

Neeta Raje

Rolf E Swenson

Sheila H DeWitt

Thomas Becker

Ioana Drutu

Narayanan Ramamurthy

Robert D Juncosa

James Daniel Frantz

Douglas John Bartels

Judith A Lippke

Dale Robert Pfost

Ralf Wörl

Aaron A Hanson

Gary J Schnerr

Sheldon M Kugelmass

Michael C Willis

Chusheng Liu

Chuseng Liu

Nagraj Mani

James C Sullivan

Eileen Z Zhang

Sheila Seepersaud

Benjamin Shames

Randal Bym

Xian-Wei Yao

Woods M Wannamaker

Christoph c/o JW Goethe University Hospital Frankfurt Sarrazin

Aaron Hanson

Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Inhibitors of influenza viruses replication

The present disclosure relates to a calibration cartridge for an in vitro medical diagnostic device. The device also includes a removable assay cartridge containing a polymer body with channels for fluid movement.

Calibration fluid cartridge for an in vitro medical diagnostic device

The present disclosure relates to an in vitro medical diagnostic device that includes a removable calibration fluid cartridge. The device also includes a removable assay cartridge containing a polymer body with channels for fluid movement.

In vitro medical diagnostic device and system

Fluid cartridge

Diagnostic device

The invention provides compounds of formula I F-L-Q (I) where F comprises a fluorophore capable of absorbing energy at an excitation wavelength and, in the absence of a quencher, emitting energy at an emission wavelength, which is different than the excitation wavelength; Q comprises a quencher; L comprises a linker moiety having two ends, one end being covalently bound to F and the other end being covalently bound to Q. The compounds are capable of undergoing a reversible reaction (1), provided below: (1) where Qis an oxidized form of Q representing the absence of a quencher, Ox comprises an oxidizing agent, which is capable of oxidizing Q to its oxidized form Q, and Red comprises a reducing agent, which is capable of converting Q back to its reduced form Q. The compounds can undergo photo-induced electron transfer when irradiated with energy and when Q exists in its oxidized form, Q. The invention also provides methods of detecting and determining the presence of analytes and/or hydrogen peroxide in a sample, as well as a substrate that comprises the compound of formula I.

Hydrogen peroxide sensors based upon photo-induced electron transfer

A slotted pin tool, a delivery system containing the pin tool, a substrate for use in the system and methods using the pin tool and system are provided. The slotted pin tool contains a plurality of pins having slotted ends designed to fit around each loci of material deposited on a surface, such as a microarray, without contacting any of the deposited material. Sample is delivered by contacting the pin tool with the surface; the amount delivered is proportional to the velocity of the pin tool as it contacts the surface or the velocity of the liquid when movement of the pin is halted.

Method and apparatus for delivery of submicroliter volumes onto a substrate

The present disclosure relates to a removable assay cartridge containing a polymer body with channels for fluid movement for an in vitro medical diagnostic device. The device also includes a removable calibration fluid cartridge.

Testing cartridge for an in vitro medical diagnostic device

Growing community of inventors

San Diego, CA, United States of America

Chao Lin