Coletica

Societe Anonyme, Bioetica

Chantal Buffevant

Alain Roger Huc

Marie-Christine Levy

Eric Perrier

Marie-Christine Andry

Isabelle Bonnet

Daniel Herbage

Patricia Lacazette

Jean Fourcart

The invention relates to small sized particles. These particles comprise at least on the surface thereof a wall composed of a mixture of at least one protein and at least one polysaccharide which are cross-linked, preferably by interfacial cross-linking with a polyfunctional acylating agent which forms at least amide and ester bonds, and optionally anhydride bonds with amine, hydroxyl or carboxyl functions of the protein and of the polysaccharide, and which comprise hydroxamic groups on the surface thereof for chelating metal ions. These particles can be used in cosmetics or in pharmacy notably for the chelation or release of metal ions.

Particles of cross-linked proteins and polysaccharides with hydroxamic

The invention relates to particles. These particles comprise, at least on the surface, a wall formed of plant proteins crosslinked particularly by means of interfacial crosslinking between the plant proteins and an acylating polyfunctional crosslinking agent comprising at least two acylating groups, covalent bonds being formed between the acylatable groups of the proteins and the acyl groups of the acylating polyfunctional crosslinking agent. These particles are used for the manufacture of a cosmetic, pharmaceutical, dermatological or food composition.

Particles of crosslinked plant proteins and the process for their

The invention relates to the use of collagen as solid binding substrate for a sensor called ligand or refining agent, capable of reacting specifically with an element to be detected in a biological medium, to form a specific complex. Preferably, the solid substrate comprises atelocollagen or a mixture of atelocollagen and of polyholoside. The invention thus makes it possible to provide a biological reactant of high specificity and of which the constituents are of natural origin. It can be used easily and quickly.

Use of a collagen as solid binding substrate for a ligand capable of

The invention relates to microcapsules with a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, and to processes for the manufacture of the said microcapsules. According to the invention, the microcapsules comprise a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, the proportion of polyholosides, for example glycosaminoglycans, relative to the atelocollagen preferably being between 18 and 50% by weight. These microcapsules can be manufactured either by a process involving interfacial crosslinking or by the extrusion of a laminar flow which is broken up by vibrations into individual droplets, which fall into a crosslinking bath. These microcapsules are biocompatible by virtue of the presence of atelocollagen, which has most of the advantageous properties of collagen, namely a very low antigenicity and a perfect biodegradability. The are therefore particularly suitable for the manufacture of cosmetic, pharmaceutical or food compositions.

Process of manufacture of biodegradable microcapsules having walls

Polysaccharide wall microcapsules containing primary alcohol functions

The invention relates to microcapsules with a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, and to processes for the manufacture of the said microcapsules. According to the invention, the microcapsules comprise a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, the proportion of polyholosides, for example glycosaminoglycans, relative to the atelocollagen preferably being between 18 and 50% by weight. These microcapsules can be manufactured either by a process involving interfacial crosslinking or by the extrusion of a laminar flow which is broken up by vibrations into individual droplets, which fall into a crosslinking bath. These microcapsules are biocompatible by virtue of the presence of atelocollagen, which has most of the advantageous properties of collagen, namely a very low antigenicity and a perfect biodegradability. They are therefore particularly suitable for the manufacture of cosmetic, pharmaceutical or food compositions.

Biodegradable microcapsules having walls composed of crosslinked

The invention relates to a composition containing liposomes, stabilized by a stabilizing support comprising a mixture of atelocollagen and glycosaminoglycans in a relative proportion preferably ranging between 18 and 25% by weight of the atelocollagen. The preferred use of this composition is in pharmacy or beauty care.

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Vernaison, France

Chantal Buffevant