Centre National De La Recherche Scientifique

Ecole Normale Superieure De Lyon

Universite Claude Bernard – Lyon1

Université Claude Bernard Lyon I

Chantal Andraud

Olivier Maury

Virginie Placide

Anh-Thy Bui

Amandine Roux

Delphine Pitrat

The present technology relates to luminescent lanthanide complexes comprising a chelating agent, formed of a macrocycle or ligand, complexing a lanthanide ion Lnselected from terbium and dysprosium, the chelating agent comprising at least one group of the structure (B) below; and a process for detecting a biomolecule using said lanthanide complex comprising coupling a luminescent lanthanide complex of the present technology having a reactive group with said biomolecule. 

Terbium and dysprosium complexes with optimised antenna, used as luminescent markers

The present invention relates to luminescent lanthanide complexes including a chelating agent, formed with a macrocycle or a set of ligands, complexing a lanthanide ion Ln3+, wherein the chelating agent is substituted with at least two groups. The invention is most particularly applied to lanthanide complexes, the chelating agent of which is formed the with three ligands integrating a 2,6 pyridine-di(carboxylic acid) or is formed with a macrocycle having a 1,4,7 triazacyclononane structure.

Lanthanide complexes comprising at least two betaine groups, which can be used as luminescent markers

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Genas, France

Chantal Andraud