The Scripps Research Institute

California Institute of Technology

The California Institute for Biomedical Research

Chanhyuk Kim

Peter G Schultz

Travis Young

Pengyu Yang

Jiayin Shen

Jennifer Ma

Jun Y Axup

Hwayoung Yun

Leonard G Presta

Ian Hardy

Eric Hampton

Eduardo Laborda

David T Rodgers

Minsoo Kim

Stephanie Pinkerton

Yu Cao

Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two or more different receptors, co-receptors, antigens, or cell markers on one or more cells. The bispecific antibodies may be used to treat a disease or condition (e.g., cancer, autoimmune disease, pathogenic infection, inflammatory disease). The bispecific antibodies may be used to modulate (e.g., stimulate or suppress) an immune response.

Targeting agent antibody conjugates and uses thereof

Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.

Optimized PNE-based chimeric receptor T cell switches and uses thereof

Disclosed herein are switchable chimeric receptors, switchable chimeric receptor effector cells and chimeric receptor effector cell switches. The switchable chimeric receptor-ECs are generally T cells. The chimeric receptors have non-antibody extracellular domains that recognize a chimeric receptor binding partner on the chimeric receptor-EC switch or target cell. The chimeric receptor-ECs and switches may be used for the treatment of a disease or condition in a subject in need thereof.

Switchable non-scFv chimeric receptors, switches, and methods of use thereof to treat cancer

Peptidic chimeric antigen receptor T cell switches and uses thereof

Growing community of inventors

San Diego, CA, United States of America

Chanhyuk Kim