Ocean University of China

The Hong Kong University of Science and Technology

China Ocean Mineral Resources R&d Association

Changyun Wang

Changlun Shao

Rufang Xu

Peiyuan Qian

Ying Sharon Xu

Meiyan Wei

Xiaofeng Mu

Kailing Wang

Hong Bai

Xia Ren

Lanting Xin

Feifei Guan

Mengqi Zhang

Xiaofeng Mou

Qing Zhao

Shijun Yue

Provided are a phenylethanoid glycoside extract from the plantL., a preparation method thereof, and its use as an anti-liver injury medicament. The preparation method of the phenylethanoid glycoside extract comprises following steps: pulverizing dried whole plantL. and passing through 20-30 mesh sieve to obtainL. powder, adding 50%-95% ethanol solution whose mass is 8-20 times of the powder, soaking and extracting under reflux, filtering and collecting extract of the powder, and extracting a filter residue under reflux with 50%-95% ethanol solution whose mass is 8-10 times of the filter residue and collecting extract of the filter residue, combining, concentrating and subjecting to macroporous resin column chromatography, eluting successively by 10%, 30% and 50% ethanol solutions for four column volumes, respectively, collecting fraction eluted by the 50% ethanol solution and drying to obtain the phenylethanoid glycoside extract.

Phenylethanoid glycoside extract fromL., preparation method thereof and use as anti-liver injury medicament

Provided is a lactam compound, a tautomer, a stereoisomer, a racemate, a nonequal mixture of enantiomers, a geometric isomer, a solvate, a pharmaceutically acceptable salt thereof, or a solvate of the salt of the compound, and a pharmaceutical composition containing the compound. Also provided are the use of such compounds and their pharmaceutical compositions as drugs, especially as antiviral drugs.

Lactam compound, preparation method and use thereof

The present invention provides alkaloids with formula I, II, III, IV, or V and their pharmaceutically acceptable salts, their preparation and their uses as antivirus drugs, for example, for treatment of HSV-1 infection. The alkaloids with formula I were isolated from the fermentation of marine fungussp. (TA01-33) by means of column chromatography, such as positive phase silica gel column chromatography, etc. Alkaloids with formula II, III, IV and V were semisynthesized from compounds with formula I.

Alkaloids and their preparation and application as anti-HSV-1 agents

Provided herein are quinolinone derivatives and their uses as antiviral drugs, for example, for treatment of HSV-1 infection. Also provided herein are pharmaceutically acceptable compositions comprising the quinolinone derivatives and the uses of the composition in the treatment of diseases caused by HSV-1 virus.

Preparation and anti-HSV-1 application of quinolinone derivatives

The present invention provides high potency 3,3'-diindolylmethane (DIM) and analogue compounds as antifouling agents. The present invention further provides methods of preventing or reducing settlement and/or fouling of marine fouling organisms on surfaces of submerged objects by coating the surfaces with the 3,3&#x2032;-diindolylmethane (DIM) and analogue compounds provided.

Diindol-3-ylmethanes as potent non-toxic antifouling compounds

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Qingdao, China

Changyun Wang