Zhejiang University

Changyou Gao

Yang Zhu

Zhengwei Mao

Liyin Shen

Xiaofei Dong

Xiaoqian Hong

Yuwen Lu

Shan Yu

Zhaolong Wang

Tanchen Ren

A suture-free coagulation-assisted fixed cardiac patch and fabrication method thereof are provided. The cardiac patch includes a polymeric procoagulant base and a barbed microneedle fixed on the polymeric procoagulant base, and a side surface of the polymeric procoagulant base with the microneedle has a microporous structure which does not penetrate the solid base of the polymer; an included angle α between the microneedle and the plane where the polymeric procoagulant base located is 60-90°, and the microneedles are evenly distributed on the polymeric procoagulant base at a density of 5-50 threads/cm2; the barbs are located on the curved surface of the microneedle and are inclined toward the polymeric procoagulant base. The fabrication method includes using a mold pore-forming, a porogen pore-forming, or a thermally induced phase separation pore-forming, and combining the barbed microneedle while forming the microporous structure to obtain a suture-free coagulation-assisted fixed cardiac patch.

Suture-free coagulation-assisted fixed cardiac patch and preparation method thereof

The present application belongs to the technical field of polymer materials, and hyperbranched polylysine powder with a low polydispersity index and a production method thereof provided. The present application adopts a thermal initiation polymerization method, Compared with the traditional method, the production method of hyperbranched polylysine has the advantages of no additional steps of introducing and removing amino protecting groups, no need of activating carboxyl groups, easy purification of products, short production period, controllable molecular weight of products and low polydispersity index (1.01-1.2), and is suitable for industrial production of hyperbranched polylysine materials, especially medical-grade hyperbranched polylysine materials.

Hyperbranched polylysine powder with low polydispersity index and production method thereof

A two-layer gradient coating article is provided that is operable to cause selective adhesion and directional migration of endothelial cells. The first layer includes cell-resisting polymers that repels cells, the second layer includes one layer of peptides that has affinity to and binds specifically to endothelial cells. Furthermore, the peptides are distributed in a gradient, in which attached ECs migrate towards the direction of increased concentration, thus enriching the ECs to a desired locus. The combination of a cell-repelling layer and a graded affinity peptide produces a unique result of selective adhesion, directional migration, thus local enrichment of endothelial cells. A method for using such gradient coating article and its potential use in treating cardiovascular diseases are also provided. The invention provides an inexpensive, stable and effective means for attracting ECs to desirable locations.

Gradient coatings of biopeptides that promote endothelial cells selective adhesion and directional migration and methods of using the same

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Hangzhou, China

Changyou Gao