Massachusetts Institute of Technology

University of Texas System

Changsok Oh

David J Yang

Ali Azhdarinia

E Edmund Kim

Firas Mourtada

Dongfang Yu

Mithu Chanda

Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X&#x2014;Y&#x2014;X, wherein Y comprises two or more carbohydrate residues covalently attached to one another, Xand Xare diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, Xand Xare diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.

Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications

The present invention provides automated systems for the purification of radioisotopes, the formulation of radiopharmaceuticals or both. In preferred embodiments the radioisotopes are produced by a generator. In further preferred embodiments the automated systems comprise replaceable cassettes for easy replacement of the system's networks of tubing. Also provided are replaceable cassettes and kits for use with the automated systems of the invention. The invention further provides methods of using an automated system to purify radioisotopes, formulate radiopharmaceuticals or to do both in series.

Automated system for formulating radiopharmaceuticals

Growing community of inventors

Houson, TX, United States of America

Changsok Oh