Massachusetts Institute of Technology

Changsik Song

Timothy Manning Swager

Robert G Griffin

Eric Dane

Kan-Nian Hu

The present invention provides methods for performing dynamic nuclear polarization using biradicals with a structure of formula (I) as described herein. In general, the methods involve (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a biradical of formula (I) and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the biradical; (c) optionally melting the sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the frozen or molten sample. The present invention also provides biradicals with a structure of formula (I) with the proviso that Qand Qare different when Xand Xare &#x2014;O&#x2014;. The present invention also provides methods for making biradicals with a structure of formula (IA) as described herein.

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Brighton, MA, United States of America

Changsik Song