Tasly Pharmaceutical Group Co., Ltd.

Changsheng Rong

Kaijing Yan

Xiaobing Sun

Liang Wang

Xuefei Cai

Xijun Yan

Shunnan Zhang

Naifeng Wu

Wensheng Zhang

Zhengliang Ye

Hongbo Zhang

Lihong Zhou

Lijun Fan

Hai'ou Dong

Xiaofeng Liu

Yongfeng Zheng

Xiaofeng LiU

Chenming Li

Cong Chen

Shiqing Wang

The present invention relates to a preparation method for a traditional Chinese medicine drop pill and a traditional Chinese medicine micro drop pill prepared by using the method, and in particular, the present invention relates to a micro drop pill preparation method with high drug-loading capacity, simple preparation process and high production rate and a micro drop pill prepared by using the method. Specially, The drop pill preparation method used comprises the following steps: (1) material melting step: heat melting a medicine and a drop pill matrix to obtain a molten medicine liquid; (2) dropping step: delivering the molten medicine liquid to a dripper, and acquiring medicine drops of the molten medicine liquid by means of vibration dropping; and, (3) condensation step: cooling the medicine drops with a cooling gas to obtain micro drop pills.

Formulation of a micro drop pill and the preparation method thereof

An intelligent dripping pill machine for continuous liquid solidification comprises: a feeding device (), a material combining device (), a homogenizing device (), a dripping device () and a de-oiling device () sequentially connected via a transmission channel. The intelligent dripping pill machine removes, via high-speed centrifugation, a cooling liquid attached to dripping pills, and each component device is connected compactly, thereby achieving a continuous manufacturing operation, and reducing an occupied space of the devices as a whole while ensuring the yield of the dripping pills.

Intelligent dripping pill machine for continuous liquid solidification

An intelligent continuous manufacturing method via liquid cooling of dripping pills comprises the following steps: (1) feeding: weighing and transferring multiple materials respectively; (2) material combining: performing staged heating on the materials transferred in step (1), and mixing the same to obtain a material mixture, wherein an RSD of an effective ingredient in the material mixture &#x2264;5%; (3) homogenizing: pressurizing the material mixture obtained in step (2), and increasing the temperature, so as to obtain a homogenized material having the RSD of the effective ingredient in the material mixture &#x2264;5%; (4) dripping: performing vibration dripping on the homogenized material obtained in step (3) to obtain dripping pills, delivering the dripping pills into a cooling liquid to be cooled and then transferred; and (5) de-oiling: removing the cooling liquid on surfaces of the dripping pills obtained in step (4) via tilting centrifugation. The manufacturing method not only shortens the manufacturing process, but also ensures the dripping pill product to be more stable and homogeneous. In addition, high-speed centrifugation is used to reasonably de-oil the dripping pills to prevent contamination of the dripping pills and improve the circulation utilization rate of the cooling liquid.

Intelligent continuous manufacturing method via liquid cooling of dripping pills

Growing community of inventors

Tianjin, China

Changsheng Rong