The General Hospital Corporation

Case Western Reserve University

Changning Wang

Jacob Matthew Hooker

Martin Georg Strebl-Bantillo

Frederick Albert Schroeder

Johanna Kaarina Rokka

Yanming Wang

Jacob M Hooker

Disclosed herein are histone deacetylase imaging agents for positron emission tomography and related imaging methods using the histone deacetylase imaging agents. The histone deacetylase imaging agents may be a compound of formula (I): wherein Ris a moiety including a positron emitter; Rrepresents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and n is an integer selected from 0 or 1. In one version of the compound of formula (I), Ris a moiety including an adamantyl group.

Imaging histone deacetylases with a radiotracer using positron emission tomography

Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prepared unlabeled and labeled compounds, diagnostic methods, and methods of treating diseases associated HDAC are also provided.

HDAC6 inhibitors and imaging agents

A molecular probe for use in the detection of myelin in a subject includes a compound having the general formula selected from the group consisting of: formula (I), and pharmaceutically acceptable salts thereof. 

Molecular probes for imaging myelin

Disclosed herein are histone deacetylase imaging agents for positron emission tomography and related imaging methods using the histone deacetylase imaging agents. The histone deacetylase imaging agents may be a compound of formula (I): wherein Ris a moiety including a positron emitter; Rrepresents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and n is an integer selected from 0 or 1. In one version of the compound of formula (I), Ris a moiety including an adamantyl group. 

Growing community of inventors

Melrose, MA, United States of America

Changning Wang