Other

Asymchem Laboratories (Tianjin) Co., Ltd.

Asymchem Life Science (Tianjin) Co., Ltd

Jilin Asymchem Laboratories Co., Ltd.

Asymchem Laboratories (Fuxin) Co., Ltd.

Tianjin Asymchem Pharmaceutical Co., Ltd.

Asymchem Life Science Co., Ltd.

Changming Dong

Hao Hong

Jiuyuan Li

Xin Hui Zhang

Lei Zhang

Gage James

James Gage

Xin Zhang

Litao Shen

A polymer containing a carboxyl group, a preparation method and an application thereof, a supported catalyst and a preparation method thereof and preparation methods of penem antibiotic intermediate are disclosed. The polymer has high rigidity and hardness, thus the mechanical properties of the polymer is effectively improved. Meanwhile, in the polymer, the carboxyl group is used as a main functional group, and is used as a carrier to prepare, by means of a coordination reaction between the carboxyl group and a heavy metal, a supported metal catalyst which has better connection stability between the metal and the polymer. The above two factors can improve the stability of the supported metal catalyst, such that the catalyst can be recycled without losing the catalytic activity. Meanwhile, loss of a heavy metal active ingredient and production cost can be reduced.

Polymer containing carboxyl group, preparation method and application thereof, supported catalyst and preparation methods thereof and preparation methods of penem antibiotic intermediate

Provided are an intermediate compound for preparing rosuvastatin calcium and a preparation method of the rosuvastatin calcium. The method comprises: using the foregoing intermediate compound as a raw material, and subjecting the raw material to a step of Wittig reaction, a step of protecting group removal and hydrolysis and a step of calcium salt formation, so as to obtain the rosuvastatin calcium. The product, which is prepared from the intermediate compound, can be substantially enhanced in stereoselectivity and also notably improved in purity and yield; in addition, the method for preparing rosuvastatin calcium from the intermediate compound is simple, convenient and low in cost. 

Intermediate compound for preparing rosuvastatin calcium and method for preparing rosuvastatin calcium therefrom

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Tianjin, China

Changming Dong