Janssen Pharmaceutica Nv

Ortho-mcneil Pharmaceutical Corp.

Changlu Liu

Timothy W Lovenberg

Steven W Sutton

Pascal Bonaventure

Chester Kuei

Jiejun Wu

Jonathan Edward Shelton

Jingcai Chen

Cindy M Pudiak

Diane Nepomuceno

Cindy W Pudiak

The chimeric polypeptide R3(B&#x394;23-27)R/I5 is described, which is a high-affinity antagonist for GPCR1 35 and GPCR1 42 over LGR7.

Chimeric peptide antagonist for GPCR135 or GPCR142

Complexes of GPR81 receptor components and ligand components, such as L-lactate or GHB, may be used as an assay reagent for screening for modulators of GPR81 receptor activity.

Methods of identifying modulators of GPR81 receptors

Chimeric polypeptides of relaxin-3, prepropolypeptides thereof, polynucleotides encoding such polypeptides, and associated expression vectors and host cells are described. The polypeptides may be used to prepare receptor-ligand complexes with GPCR135 or GPCR142, which may be used in assay methods.

Relaxin-3 chimeric polypeptides and their preparation and use

Canine 5-hydroxytryptamine 2 receptor materials are described, including polypeptides corresponding to SEQ ID NOs.:8 and 10 and polynucleotides expressing them corresponding to SEQ ID NOs.:7 and 9. Such materials are useful as reagents in drug screening assays to identify compounds having 5-HTreceptor-modulating activity.

Canine 5-hydroxytryptamine 2A and 2B receptor

A PK2&#x3b2; peptide is described, which, as an agonist of prokineticin receptor 1, is useful for treating lung and gastrointestinal diseases or disorders mediated by PKR1 activity.

Prokineticin 2&#x3b2; peptide and its use

DNAs encoding the mammalian histamine H4 receptors have been cloned and characterized. These recombinant molecules are capable of expressing biologically active histamine H4 receptor protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The pharmacology of known histamine ligands is demonstrated. The recombinant protein may be purified from the recombinant host cells. In addition, recombinant host cells are utilized to establish methods to identify modulators of the receptor activity, and receptor modulators are identified.

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San Diego, CA, United States of America

Changlu Liu