Tianjin Institute of Pharmaceutical Research

Tianjin Institute of Pharmaceutical Research Co., Ltd.

Changjiang Huang

Lida Tang

Lei Liu

Peng Liu

Weiren Xu

Meixiang Zou

Wei Wei

Yuquan Li

Bingni Liu

Shijun Zhang

Chubing Tan

Xuyuan Liu

Ying Liu

Yunsong Zhou

Yigui Zhao

Deguang Zhi

Mo Liu

Lingjun Li

Jing Yuan

Hui Yan

Songhui Wang

Xuemin Zheng

Qunchao Wei

Dengke Liu

Nan Yue

Furong Chen

The present invention provides a compound having a structure of formula (I), a preparation method and use thereof, and a pharmaceutical composition containing the compound, wherein R is methyl, ethyl, propyl, vinyl or propenyl. The present invention also provides a crystalline form of the compound, a preparation method and use of the crystalline form, and a pharmaceutical composition comprising the crystalline form. The compounds having the structure of formula (I) of the present invention are present in a solid form, which not only can solve the problem of clopidogrel resistance, but also can solve the problem of severe hemorrhagic side effect and poor safety of some drugs, as well as the problem of poor stability of existing compounds. It can be developed into an ADP receptor antagonist antiplatelet agent with clear therapeutic effect, no resistance and better stability. 

Thienopyridine derivatives containing unsaturated aliphatic olefinic bond, preparation method and use thereof

A compound with the structure of the formula (I) or a pharmaceutically acceptable salt, a preparation method and use thereof are disclosed in the present invention, wherein R is cyano group. The compound provided by the present invention has an antiplatelet aggregation activity and can be used in preparing a medicament for preventing or treating cardiac and cerebral vascular diseases such as coronary artery syndromes, myocardial infarction and myocardial ischemia which are caused by platelet aggregation. 

Thienopyridine ester derivative containing cyano group, preparation method, use and composition thereof

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Tianjin, China

Changjiang Huang