University of Saskatchewan

The University of British Columbia

Wang, Yu Tian

Taghibiglou, Changiz

Changiz Taghibiglou

Yu Tian Wang

Shu Zhang

Clarence Ronald Geyer

Nathan Pham

Landon Pastushok

The present disclosure relates to a method for detecting a brain injury in a subject by comparing the amount of ADAM10 protein in a blood sample from the subject to a reference standard or to the amount of ADAM10 in a blood sample from a control. An increase in the amount of ADAM10 in the subject blood sample relative to the reference standard or control is indicative of the subject having sustained a brain injury, in particular a traumatic brain injury (TBI). The present disclosure also provides novel antibody and antibody fragments that bind to ADAM10 at different positions.

ADAM-10 as a biomarker for detecting brain injury

The present application provides compositions, methods, and uses of polypeptide or antibody inhibitors of insig-1 ubiquitination for preventing or treating skin diseases or conditions associated with overproduction of sebum, such as acne and seborrhea.

Polypeptides and antibodies to treat skin conditions associated with overproduction of sebum

The disclosure provides methods of detecting and monitoring brain injury in a test subject comprising analyzing a blood sample from the test subject for increased levels of PrP. The disclosure also provides kits for measuring the amount of PrPin a blood sample.

Methods and kits for detecting brain injury

Described herein are isolated polypeptides having phosphatase and tensin homolog (PTEN) inhibitory activity, vectors and cells for the expression thereof and methods for their use in treating diseases associated with cytotoxic stress, such as spinal cord injury, stroke, traumatic brain injury, multiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease, and Huntington's disease.

Growing community of inventors

Saskatoon, Canada

Changiz Taghibiglou