Precigen, Inc.

ChangHung Chen

Rutul R Shah

Cheryl G Bolinger

Helen Sabzevari

Simon Metenou

Vinodhbabu Kurella

Amy Wesa

Provided herein are chimeric antigen receptors (CARs) for cancer therapy, and more particularly, CARs containing a scFv from an anti-ROR-1 monoclonal antibody. Provided are immune effector cells containing such CARs, and methods of treating proliferative disorders.

ROR-1 specific chimeric antigen receptors and uses thereof

Provided herein is a composition comprising a fusion protein or a fragment or a variant thereof comprising an anti-PD1 antibody or a fragment/variant thereof and a TGF-&#x3b2; trap. Provided herein is a composition comprising a fusion protein or a fragment thereof or a variant thereof comprising an anti-PD1 antibody or a fragment/variant thereof and a ADA2 polypeptide. Also provided herein are methods of using the composition in treating cancer.

Fusion constructs and methods of using thereof

Growing community of inventors

Blacksburg, VA, United States of America

ChangHung Chen