California Institute of Technology

Massachusetts Institute of Technology

Hi LLC

Duke University

Northeastern University

London School of Hygiene and Tropical Medicine

The General Hospital Corporation

Washington University

Case Western Reserve University

City of Hope

City of Hope, a Non-Profit Charitable Organization

Changhuei Yang

Guoan Zheng

Roarke W Horstmeyer

Xiquan Cui

Xiaoze Ou

Shuo Pang

Michael S Feld

Jamu Alford

Adam H Marblestone

Jigang Wu

Demetri Psaltis

Ramachandra Rac Dasari

Xin Heng

Benjamin Judkewitz

Axel Scherer

Jian Xu

Ying Min Wang

Daniel Sobek

Gabriel Popescu

Haowen Ruan

Meng Cui

Christopher M Fang-Yen

Guillermo J Tearney

Joseph A Izatt

Charles A DiMarzio

Sri Rama Prasanna Pavani

Andrei Faraon

Christian T Wentz

Andrew M Rollins

David Erickson

Adam P Wax

Jaebum Chung

Seung Ah Lee

Jinho Kim

Samuel Yang

Joshua Brake

Zahid Yaqoob

Michael Choma

Mooseok Jang

Cheng Shen

Lap Man Lee

Jian Ren

Yu Horie

Jacob Berlin

Richard J Cote

Lev T Perelman

Sylvain Gigan

Chi Shing Chan

Siavash Yazdanfar

Ivo Vellekoop

Brian E Applegate

Edward H Zhou

Tom Haber

Lily L Lai

Christopher Fang-yen

Emily McDowell

Jiangtao Huangfu

Zheng Li

Marinko Sarunic

Fei Wang

Divakar K Rao

Chao Han

Atsushi Shibukawa

Daifa Wang

Yuhua Chen

Magdalena D Zernicka-Goetz

Joel A Tropp

Adiyant Lamba

Siddarth Rawal

Disclosed herein include systems, devices, and methods for detecting embryo polarization from a 2D image generated from a 3D image of an embryo that is not fluorescently labeled using a convolutional neural network (CNN), e.g., deep CNN.

Stain-free detection of embryo polarization using deep learning

Systems, devices, and methods of Fourier ptychographic imaging by computationally reconstructing a high-resolution image by iteratively updating overlapping regions of variably-illuminated, low-resolution intensity images in Fourier space.

Fourier ptychographic imaging systems, devices, and methods

Computational refocusing-assisted deep learning methods, apparatus, and systems are described. In certain pathology examples, a representative image is generated using a machine learning model trained with uniformly focused training images generated by a Fourier ptychographic digital refocusing procedure and abnormalities are automatedly identified and/or enumerated based on the representative image.

Computational refocusing-assisted deep learning

A communication system including a first detector; a first scattering medium; a second detector; an intensity modulator; a second scattering medium; wherein electromagnetic radiation transmitted from a first spot at the first scattering medium, and scattered by and through the first scattering medium and then the second scattering medium, forms a first speckle pattern detected by the second detector. The intensity modulator outputs a second spot of electromagnetic radiation representing the 'ones' in a data stream at locations of the bright speckles (or at locations of the dark speckles to represent the “zeros” in the data stream) so that the electromagnetic radiation, transmitted from the second spot and scattered by and through the second scattering medium and then the first scattering medium, forms one or more second bright or dark speckles on the first detector. The data stream can be constructed from the second bright or dark speckles.

Optical channel intensity streaming encryption

Interferometric speckle visibility spectroscopy methods, systems, and non-transitory computer readable media for recovering sample speckle field data or a speckle field pattern from an off-axis interferogram recorded by one or more sensors over an exposure time and determining sample dynamics of a sample being analyzed from speckle statistics of the speckle field data or the speckle field pattern.

Interferometric speckle visibility spectroscopy

Optical wavefront shaping has been the standard technique to control light through scattering media. Implicit in this dominance is the assumption that knowledge of the optical phase is a necessity for optical control through scattering media. In this paper, we challenge this assumption by reporting on an intensity-only approach for light control through (or reflected from) a disordered scattering medium&#x2014;optical-channel-based intensity streaming (OCIS). Instead of actively tuning the interference between the optical paths via wavefront shaping, OCIS can control light and transmit information through or from scattering media with linear intensity operation, which not only simplifies and speeds up the system but also enables new applications. We experimentally created focus patterns through scattering media in a sub-millisecond timescale with a phase-manipulation-free setup. We also demonstrate that, unlike wavefront shaping, OCIS can readily generate distinct energy null points through scattering media. Finally, we demonstrate that OCIS enables a scattering medium mediated secure optical communication application.

Control light intensity through scattering media with speckle intensity sequencing

A 3-D imaging system including a computer determining a plurality of coherence factors measuring an intensity contrast between a first intensity of a first region of an interference comprising constructive interference between a sample wavefront and a reference wavefront, and a second intensity of a second region of the interference comprising destructive interference between the sample wavefront and the reference wavefront, wherein the interference between a reference wavefront and a reflection from different locations on a surface of an object. From the coherence factors, the computer determines height data comprising heights of the surface with respect to an x-y plane perpendicular to the heights and as a function of the locations in the x-y plane. The height data is useful for generating a three dimensional topological image of the surface.

Three dimensional (3D) imaging using optical coherence factor (OCF)

Certain aspects pertain to Fourier camera systems and methods. In one aspect, a Fourier camera comprises a first optical system, a second optical system, a variable aperture filter, and a light detector. The first optical system configured to receive illumination reflected from a curved sample surface. The variable aperture filter configured to move an aperture to a plurality of aperture locations in a Fourier plane, wherein the aperture filters light from the first optical system to the second optical system. The light detector configured to receive light from the second optical system, and configured to acquire a plurality of raw intensity images of the curved sample surface corresponding to the plurality of aperture locations, wherein the raw images are iteratively updated in overlapping regions in Fourier space to generate a focused, substantially uniform resolution image of the curved sample surface, and wherein the overlapping regions correspond to the plurality of aperture locations.

Free orientation fourier camera

A magnetic field controlled guidestar for focusing light deep inside scattering media using optical phase conjugation. Compared with the optical and ultrasonic field, the magnetic field has an exceptional penetration depth. The magnetic particle guidestar has a high light-tagging efficiency, good biocompatibility, and a small diameter which enables a sharp and bright focusing deep inside biological tissue. This new method can benefit a wide range of biomedical applications including deep-tissue imaging, neural modulation, and targeted photothermal and photodynamic therapies.

Focusing light inside scattering media with magnetic particle guided wavefront shaping

Certain embodiments pertain to techniques for coded-aperture-based correction of sample-induced and system-induced aberration.

Systems and methods for coded-aperture-based correction of aberration obtained from Fourier ptychography

An optical detection method and system are provided. Sample light is delivered into an anatomical structure having a target voxel, whereby a portion of the sample light passing through the target voxel is scattered by the anatomical structure as signal light, and another portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light that is combined with the signal light to create a sample light pattern. The sample light pattern and the reference light having an M number of different phases are concurrently combined to respectively generate an M number of interference light patterns. The M number of interference light patterns are detected. M pluralities of values representative of spatial components of the respective M number of interference light patterns are generated, and a physiologically-dependent optical parameter of the target voxel is determined based on the M pluralities of values.

System and method for simultaneously detecting phase modulated optical signals

An integrated sensor and optical phase/amplitude modulator device including a modulator stacked on or above a detector. A circuit receives a signal outputted from the detector in response to an input field irradiating the detector. The circuit performs binary operations comprising classifying the input phase of the input electromagnetic radiation into one of two ranges and setting the modulator into one of two states depending on which range the input phase is classified into. The modulator transmits output electromagnetic radiation having an output field modulated according to the state of the modulator set by the circuit.

Concepts pertaining to integrated sensor and optical phase/amplitude modulator

Described herein are systems and methods for noninvasive functional brain imaging using low-coherence interferometry (e.g., for the purpose of creating a brain computer interface with higher spatiotemporal resolution). One variation of a system and method comprises optical interference components and techniques using a lock-in camera. The system comprises a light source and a processor configured to rapidly phase-shift the reference light beam across a pre-selected set of phase shifts or offsets, to store a set of interference patterns associated with each of these pre-selected phase shifts, and to process these stored interference patterns to compute an estimate of the number of photons traveling between a light source and the lock-in camera detector for which the path length falls within a user-defined path length range.

Systems and methods for quasi-ballistic photon optical coherence tomography in diffusive scattering media using a lock-in camera detector

Certain aspects pertain to multi-well systems, devices, and methods of Fourier ptychographic and fluorescence imaging.

Multi-well fourier ptychographic and fluorescence imaging

Growing community of inventors

Pasadena, CA, United States of America

Changhuei Yang