Rmx, LLC

Amaranth Medical Pte.

Ramzipoor, Kamal

Chang Y Lee

Amir J Tehrani

Rose Province

David Ligon

Amy Michelle Goodman

Kamal Ramzipoor

Fozan El-Nounou

Alfred N K Chia

Liwei Wang

Drew Hoffmann

Alan Richard Schwartz

David Hillman

Peter Eastwood

Edward A Estrada

Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape.

Stent fabrication via tubular casting processes

Bioresorbable scaffolds for treatment of bifurcation lesion are described herein. Generally, an expandable scaffold may be fabricated from a high molecular weight isotropic PLLA material, wherein the scaffold incorporates one or more strain relief features which are configured to allow side branch treatment.

Bioresorbable scaffold for treatment of bifurcation lesion

A device and method is provided for biasing lung volume by electrically stimulating tissue associated with the diaphragm or phrenic nerve at a low level.

Device for manipulating tidal volume and breathing entrainment

A device and method is provided for increasing the functional residual capacity of lungs of a subject by electrically stimulating tissue associated with the diaphragm or phrenic nerve of the subject.

Device and method for manipulating exhalation

Sterilization methods for implantable prostheses are described where a polymeric stent may be sterilized, e.g., via ETO sterilization, at a temperature below a glass transition temperature of the stent. A separate delivery catheter may be sterilized separately and the stent and delivery catheter may then be combined in an aseptic or semi-aseptic environment and sterilized as an assembled system such that the requirements for sterilizing the system are relatively lower. Additionally and/or alternatively, valve and filter assemblies may be used with an optional mandrel assembly for maintaining sterility of the internal components of a catheter system.

Sterilization methods and apparatus

Sterilization methods for implantable prostheses are described, where a polymeric stent may be sterilized, e.g., via ETO sterilization, at a temperature below a glass transition temperature of the stent. A separate delivery catheter may be sterilized separately and the stent and delivery catheter may then be combined in an aseptic, or semi-aseptic environment and sterilized as an assembled system such that the requirements for sterilizing the system are relatively lower. Additionally and/or alternatively, valve and filter assemblies may be used with an optional mandrel assembly for maintaining sterility of the internal components of a catheter system.

A device and method is provided for therapeutic stimulating, augmenting, manipulating and/or controlling breathing, in combination with stimulation of auxiliary respiratory nerves or muscles including the upper airway tract, chest wall muscles or abdominal muscles. Stimulation may be provided, for example, to augment breathing or to prevent closing of the upper airway during therapeutic stimulation. Stimulation may be also provided to the Hypoglossal nerve during exhalation.

Multimode device and method for controlling breathing

A device and method are provided for treating obstructive respiratory events by electrically stimulating tissue associated with the phrenic nerve or diaphragm to elicit a respiratory response.

Device and method for treating obstructive sleep apnea

A device and method for treating a variety of conditions, disorders or diseases with diaphragm/phrenic nerve stimulation is provided.

Therapeutic diaphragm stimulation device and method

Device and method for biasing and stimulating respiration

A device and method is provided for controlling breathing of a subject by electrically stimulating tissue associated with the diaphragm or phrenic nerve of the subject.

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Redwood City, CA, United States of America

Chang Y Lee