Other

North Carolina State University

Sicel Technologies, Inc.

Chang-Soo Kim

Charles W Scarantino

H Troy Nagle

Jason Oliver Fiering

Bahram Ghaffarzadeh Kermani

Jeffrey S Mueller

Stefan Ufer

Leslie C Hall

Calibration of in vivo oxygen and pH sensor systems can be performed by generating a constituent element of an environment proximate to an in vivo sensor electrode via an in vivo generating electrode and determining a level of the constituent element in the tissue via the in vivo sensor electrode. Accordingly, accurate monitoring of tissue can be achieved while reducing the need to calibrate the in vivo sensor systems using invasive procedures. Related electrode assemblies are also discussed.

Methods, computer program products, and devices for calibrating chronically tissue implanted sensors using chronically tissue

Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an in situ located sensor to a receiver external of the subject, analyzing the transmitted data, repeating the monitoring and transmitting steps at sequential points in time and evaluating a treatment strategy. The method provides dynamic tracking of the monitored parameters over time. The method can also include identifying in a substantially real time manner when conditions are favorable for treatment and when conditions are unfavorable for treatment and can verify or quantify how much of a known drug dose or radiation dose was actually received at the tumor. The method can include remote transmission from a non-clinical site to allow oversight of the tumor's condition even during non-active treatment periods (in between active treatments). The disclosure also includes monitoring systems with in situ in vivo biocompatible sensors and telemetry based operations and related computer program products.

Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors

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Cary, NC, United States of America

Chang-Soo Kim