China University of Mining and Technology (CUMT)

Shenzhen University

Beijing Xiaomi Mobile Software Co., Ltd.

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Lianyungang Runzhong Pharmaceutical Co., Ltd.

Shouyao Holdings (Beijing) Co., Ltd.

Shouyao Holdings Co., Ltd.

Chang Lu

Hongbin Liu

Yang Ju

Yan Zhu

Zhangyu Ren

Xiaodong Nie

Changbing Wan

Lei Wang

Heping Xie

Feng Gao

Jinxin Song

Peng Liu

Yu Wang

Ling Yang

Hongjiang Xu

Xin Tian

Yinghui Sun

Xijie Liu

Ying Sun

Yating Wang

Xiaowei Duan

Huting Wang

Jijun Li

Hongli Chen

Xianxing Shang

Qin Yan

Xiaolan Li

Jiuqing Zhang

Yeliu Wang

Weinan He

Baokun Yuan

Wangyang Min

Jinsuo Yao

Deng Hou

Nan Jiao

Yeling Ji

The present invention relates to a iminosulfanone compound represented by formula (I) as a bromodomain protein inhibitor and a pharmaceutically acceptable salt thereof and to a preparation method, pharmaceutical composition, and medical use thereof.

Iminosulfanone compound as bromodomain protein inhibitor and pharmaceutical composition and medical use thereof

Display screen or portion thereof with graphical user interface

An automatic coal mining machine and a fluidized coal mining method are provided. A first excavation cabin is configured to cut coal seam to obtain raw coal and to be transported to a first coal preparation cabin for separating coal blocks from gangue. Then, the obtained coal blocks are transported to a first fluidized conversion reaction cabin. The first fluidized conversion reaction cabin converts the energy form of the coal block into liquid, gas or electric energy, which is transported to a first energy storage cabin for storing. Coal mining and conversion are carried out in underground coal mines, so it is not necessary to raise coal blocks to the ground for washing and conversion, thereby reducing the transportation cost of coal, improving the utilization degree of coal, and avoiding the pollution of the ground environment caused by waste in the mining and conversion process.

Automatic coal mining machine and fluidized coal mining method

A mine field layout method suitable for fluidized mining of coal resources is provided. A main shaft and an air shaft are provided in the mine field, the bottom of the main shaft is located in the shallow horizontal coal seam zone, and the bottom of the air shaft is located in the deep horizontal coal seam zone. The horizontal main roadways are arranged at two boundaries along the strike of the coal seam, and inclined main roadways are arranged at two boundaries along the dip direction of the coal seam. Connecting roadways are located inside the mine field and are in communication with the horizontal main roadways. In the coal mining stage, the coal resources can be converted into the fluidized energy product and/or electricity by an unmanned automatic mining machine.

Mine field layout method suitable for fluidized mining of coal resources

A transparent constraint apparatus for the normal deformation of a planar model, including rigid transparent retainer plates, a planar model, and magnetic force components. The magnetic force components are provided at edge positions of the rigid transparent retainer plates; the normal direction of the planar model is parallel to the normal direction of the two rigid transparent retainer plates, and said two retainer plates are symmetrically arranged relative to the plane of symmetry of the planar model; the magnetic force components are symmetrically arranged relative to the plane of symmetry of the planar model, mutually symmetrical magnetic force components producing mutually attractive magnetic force. The transparent constraint apparatus solves the problem of constraining the normal deformation of a planar model under planar-strain conditions during testing.

Transparent constraint apparatus for normal deformation of planar model

Growing community of inventors

Beijing, China

Chang Lu