Korea Institute of Science and Technology

Chang-Keun Lim

Sehoon Kim

Ick Chan Kwon

Jeongyun Heo

Jai Kyeong Kim

Kuiwon Choi

Kwangmeyung Kim

Kwang Meyung Kim

Jeong Eun Heo

Keunsoo Jeong

The present invention relates to a nanogel comprising a polyamine-based polymer cross-linked by oxamide bonds, a preparation method of the nanogel, a contrast agent for ultrasound imaging comprising the nanogel, a composition for ultrasound diagnosis of inflammatory diseases comprising the contrast agent, a preparation method of the contrast agent, and a method for providing information for diagnosis of inflammatory diseases using the composition for ultrasound diagnosis.

Oxamide nanogel, a preparation method of the same, and use thereof

The present disclosure relates to a sulfonated benzene compound emitting fluorescence by reaction with hydrogen peroxide, aqueous-dispersed fluorescent nanoprobes applicable for real-time detection of hydrogen peroxide, and a fluorescent nanoprobe fabrication method. The fluorescent nanoprobe contains the following sulfonated benzene compound and water. 

Fluorescent nanoprobe for detecting hydrogen peroxide and fabrication method thereof

Disclosed are nanoparticles of a light emissive polymer, comprising nanoparticles of a cyano-substituted poly(arylene vinylene) polymer; and a biocompatible surfactant adsorbed to the surface of the nanoparticles of the polymer, and preparation method thereof, wherein the method comprises: (1) uniformly mixing a dialdehyde monomer represented by a general formula OHC&#x2014;Ar&#x2014;CHO, a dicyanide monomer represented by a general formula NC&#x2014;Ar&#x2014;CN, and a liquid surfactant; (2) adding water to the resulting mixture to prepare an aqueous micelle dispersion; and (3) adding a polymerization catalyst to the aqueous micelle dispersion, followed by carrying out colloidal polymerization of the resulting mixture at room temperature under an atmosphere. The nanoparticles of the light emissive polymer of the invention are stabilized with a biocompatible surfactant, so that it can form a stable aqueous dispersion phase, and has particle size and fluorescence efficiency suitable for a biomolecular marker or a cell or in vivo imaging; therefore, it can be used as a cell or in vivo light emission contrast agent.

Nanoparticles of light emissive polymers and preparation method thereof

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Seoul, South Korea

Chang-Keun Lim