Incube Labs, LLC

Rani Therapeutics, LLC

Chang Jin Ong

Mir A Imran

Timothy H Williams

Baber R Syed

Peter Herrmann

Greg Method

Timothy John Williams

Glen W McLaughlin

Mir Hashim

Joel M Harris

Radhika Korupolu

Sanjay V Patel

Lu Wang

Andrew Mangogna

Huma Arastu

Rekha Vaidyanathan

Arthur Hsu Chen Chang

Delia Anna Gratta

Baber Syed

Glen Mclaughlin

Sanjay Patel

Timothy Williams

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to a delivery mechanism having one or more balloons or other expandable devices which are expandable responsive to a condition in the small intestine or other GI lumen to advance the preparation out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

Device, system and methods for the oral delivery of therapeutic compounds

Embodiments provide methods and apparatus for manufacturing a microtablet from a precursor material such as a pharmaceutical powder. Various embodiments provide a method which includes compressing the powder to form a compressed mass of a selected density and repeatedly compacting the compressed mass to increase the density of the compressed mass and form a microtablet. Related methods and apparatus are provided.

Method and apparatus for manufacturing microtablets

Apparatus for manufacturing microtablets

Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

System and method for biphasic transdermal iontophoretic therapeutic agents

System and method for biphasic transdermal iontophoretic delivery of therapeutic agents

System and method for biphasic transdermal iontophreotic delivery of therapeutic agents

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Fremont, CA, United States of America

Chang Jin Ong