St Pharm Co., Ltd.

Chang Ho Byeon

Sun Ki Chang

Geun Jho Lim

Moon Soo Kim

Hoe Jin Yoon

Geun Gho Lim

The present disclosure relates to a novel method for preparing high-purity gadobutrol. The present disclosure can be easily applied to a large scale production because purity of intermediate can be managed via simple and mild process and accordingly, high-purity or ultra high-purity gadobutrol that has higher purity than previous gadobutrol can be prepared in high yield therethrough.

Method for preparing gadobutrol

Disclosed is a novel method of preparing highly pure calcobutrol using an intermediate (butrol) of gadobutrol without using highly pure gadobutrol. This method is capable of obtaining calcobutrol at high purity and high yield through a simple and environmentally friendly process, and thus can be easily applied to mass production.

Method for preparing calcobutrol

The present invention provides a method which enables the simple, economical and high-yield production which is a key intermediate of antidiabetic drug Januvia.

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Gyeonggi-do, South Korea

Chang Ho Byeon