Rexahn Pharmaceuticals, Inc.

Rexahn Corporation

Other

University System of Maryland

The Ohio State University

Korea Research Institute of Chemical Technology

Chang Ho Ahn

Young Bok Lee

Deog Joong Kim

Won-Jea Cho

Won Jun Choi

Robert J Lee

Jae Yang Kong

Sang Kook Lee

Young-Dae Gong

Lak Shin Jeong

Hamidreza Ghandehari

Moon-Kook Jeon

Abhijit Ray

Dong-Su Kim

Gun-Do Kim

Heejeong Yoon

Lingjun Mao

Anjan Nan

Described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a targeting agent. The composition can include a therapeutic agent. The therapeutic agent can be an antisense oligonucleotide (ASO). Exemplary ASOs are targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1; or targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Also described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a therapeutic agent that is an ASO such as an ASO targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1 or an ASO targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Pharmaceutical formulations, methods of making the lipid nanoparticles, and methods of using the lipid nanoparticles, for example for treating cancers, are also disclosed.

Lipid nanoparticle compositions for antisense oligonucleotides delivery

Disclosed are water-soluble compositions of gemcitabine and docetaxel formed by conjugating the gemcitabine or docetaxel to a water-soluble polymer such as N-2-hydroxypropyl methacrylamide (HPMA). Also disclosed are methods of using the compositions of the invention for the treatment of cancer.

HPMA&#x2014;docetaxel conjugates and uses therefore

The present invention relates to compositions for the treatment of cancerous tissues in warm-blooded animals containing one or two anticancer agents attached to polymeric carriers having monomer units derived from one or more of N-(2-carboxypropyl)methacrylamide (2-CPMA), N-(3-carboxypropyl)methacrylamide (3-CPMA), N-(2-aminopropyl)methacrylamide (2-APMA) and/or N-(3-aminopropyl)methacrylamide (3-APMA) are also included. Anticancer agents in compositions can be attached to said polymeric carrier by side-chains which can be susceptible to hydrolysis by lysosomal enzymes intracellularly. Compositions can also include a targeting ligand attached to the polymeric carrier, optionally through a second linker.

Polymeric systems for the delivery of anticancer drugs

The present invention relates to novel quioxaline-piperazine compounds, 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives of formula (1): and their pharmaceutically acceptable salts, a process for their preparation thereof, and compositions containing such compounds. Therapeutic methods for the treatment of hyperproliferative disorders, including cancers, by administering quioxalin-piperazine compounds are also included.

1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives for treating tumors

Quinazoline derivatives represented by the general formula pharmacologically acceptable salts thereof, and compositions containing such compounds are described. Methods for using the compounds for treatment of hyperproliferative disorders are also disclosed.

Quinazoline derivatives and therapeutic use thereof

The present invention relates to 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives represented by general formula D, their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included. 

5, 6, or 7-substituted -3-(hetero) arylisoquinolinamine derivatives and therapeutic use thereof

5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives and therapeutic use thereof

The present invention relates to nucleoside derivatives represented by general formulas I and II, their synthetic methods and their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included. 

Nucleoside derivatives and therapeutic use thereof

Quinazoline derivatives represented by the general formula pharmacologically acceptable salts thereof, and compositions containing such compounds are described. Methods for using the compounds for treatment of hyperproliferative disorders are also described.

New antisense oligonucleotide compounds inhibit expression of Akt-1 and also induce cytotoxicity in several cancer cell lines.

Use of antisense oligonucleotides to inhibit the expression of human Akt-1

An apparatus and method for the attachment of supplemental hair to existing natural hair. The apparatus comprising a first comb member, a handle attached at a back end thereof, and a second comb member hingeably or pivotally attached thereto. A row of first teeth extends from the first comb member corresponding to a row of second teeth extending from the second comb member. The second comb member is positioned to be moveable interchangeably between a closed position and an open position. A heating member connects to and provides heat to one or both of the first comb member and second comb member. The apparatus is utilized in a process to attach supplemental hair to existing natural hair of a person's head. The method uses rows of supplemental hair pre-attached to a band member. An adhesive member is pre-hardened on each row of supplemental hair at a predetermined distance near the band member. With the second comb member in the open position, the rows of supplemental hair strands of natural hair are placed between each tooth of the row of first teeth. The second comb member is moved to the closed position for a predetermined period of time long enough to allow the pre-hardened adhesive to melt sufficiently to adhere the rows of supplemental hairs.

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Potomac, MD, United States of America

Chang Ho Ahn