Yonsei University

Aat Costech Co., Ltd.

Db Hitek Co., Ltd.

Newtree Co., Ltd.

Cosmax Nbt, Inc.

Cosmax Ns, Inc.

Chang Hee Kim

Jae Kwan Hwang

Mi Bo Kim

Mi-Bo Kim

Jung Hyun Lee

Jin Hyo Jung

Jin Hak Kim

Jae-Kwan Hwang

Su Young Choi

Seung Ha Lee

Heechul Chung

Bum Seok Kim

Doun Kim

Jeong Ho Geum

Joon Hyung Lee

Ji Hwan Jang

Hyeongmin Kim

Se In Lee

Min Son Kweon

Seung Tae Su

Ji Hee Yoo

Jun Gon Yun

Do Wan Kwon

Seon Wook Woo

Jong Wook Kim

The present invention relates to a composition for preventing or treating muscular diseases, or for improving muscular functions, containing gagnlioside. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating muscular diseases, a food composition for preventing or alleviating muscular diseases, or a cosmetic composition for preventing or alleviating muscular diseases, all of which comprise gagnlioside, which can increase the expression of proteins associated with muscle protein synthesis and muscle mass growth in muscle cells and inhibit the expression of enzymes involved in muscle protein degradation at the mRNA level.

Composition for preventing or treating muscular diseases, or for improving muscular functions, containing ganglioside

The present invention relates to a composition for preventing or treating a muscle disorder, which includes a chrysanthemum extract or 3,5-dicaffeoylquinic acid as an active ingredient, and specifically, it may be used to reduce mRNA expression of atrogin-1 and MuRF1, which are main biomarkers involved in muscle protein degradation and increase mRNA expression of the mTOR protein, which is a main biomarker involved in muscle protein formation, and myogenin and MyoD, which are biomarkers related to muscle differentiation, thereby reducing muscle loss, and thus the chrysanthemum extract or 3,5-dicaffeoylquinic acid can be used in prevention and treatment of a muscle disorder, or improvement in muscle function. In addition, the chrysanthemum extract or 3,5-dicaffeoylquinic acid increases the activity of SIRT1 and PGC-1&#x3b1;, which are the main biomarkers involved in exercise performance, thereby excellently enhancing exercise performance. In addition, the present invention is a natural substance and may be safely used without a side effect, and therefore may be used as a medication, food or a cosmetic.

Composition for improvement of muscle function containing 3,5-dicaffeoylquinic acid or chrysanthemum extract

var.according to the present invention is capable of increasing muscle mass and enhancing muscular function or exercise performance through an effect of promoting mRNA or protein expression and the activity of a gene involved in muscle functions, muscle mass increase of differentiation of muscle cells; can prevent, treat or ameliorate a decline in exercise performance, a decline in muscle function, muscle loss, etc. caused by various diseases; and may be effectively used for medicines or food products, etc., since it has no side effects in the body as natural substance.

Composition for improving muscular function or for enhancing exercise performance comprising vigna angularis var. angularis

A composition for preventing or treating muscle diseases or improving muscular function, containing fucosterol,, adried powder, aextract,, adried powder or aextract is disclosed. Fucosterol,, adried powder, aextract,, adried powder or aextract increases the protein expression of p-mTOR, which is a main gene involved in muscle protein synthesis, inhibits the mRNA expression of MuRF-1 and atrogin-1 involved in muscle protein degradation, and increases the mRNA expression of MyoD and myogenin involved in muscle differentiation, thereby having an effect of remarkably increasing muscular function. In addition, the composition can be safely used without side effects, thereby being usable in medicine, food, cosmetic products, livestock feed, a feed additive and the like.

Composition for preventing, alleviating or treating muscle diseases or improving muscular function

The present invention relates to a composition for muscle function improvement or exercise ability enhancement, the composition including kirenol, aextract, or a fraction of theextract as an active ingredient. Kirenol, theextract containing kirenol, or theextract fraction according to the present invention has an excellent effect of increasing muscle mass by increasing the protein expression of p-mTOR, which is a major gene concerned with muscle functions. Also, kirenol, theextract containing kirenol, or theextract fraction according to the present invention has an effect of remarkably enhancing exercise ability by increasing the protein expression of PGC-1&#x3b1;, which is a major gene concerned with exercise ability. In addition, the present invention is a natural product, and thus is safe for use without side effects and can be used as a medicine or food.

Composition including kirenol or siegesbeckia herba extract for muscle function improvement or exercise ability enhancement

The present invention relates to a novel use of fucosterol and, more specifically, to a composition for skin whitening or composition for skin moisturizing, which is characterized by containing fucosterol. Fucosterol of chemical formula 1 below has an excellent whitening effect of inhibiting melanin generation and tyrosinase activity, and thus can be used as an active ingredient of a cosmetic composition for whitening, a food composition, or a pharmaceutical composition. Furthermore, the fucosterol of chemical formula 1 below has an excellent moisturizing function by forming dead skin cell membranes, promoting the differentiation of dead skin cells, and generating natural moisturization factors, and thus can be used as an active ingredient of a cosmetic composition for moisturizing, a food composition, or a pharmaceutical composition 

Composition containing fucosterol for skin whitening or moisturizing

In embodiments, a high voltage semiconductor device includes a gate structure disposed on a substrate, a source region disposed at a surface portion of the substrate adjacent to one side of the gate structure, a drift region disposed at a surface portion of the substrate adjacent to another side of the gate structure, a drain region disposed at a surface portion of the drift region spaced from the gate structure, and an electrode structure disposed on the drift region to generate a vertical electric field between the gate structure and the drain region.

High voltage semiconductor device and method of manufacturing the same

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Seoul, South Korea

Chang Hee Kim