Samsung Electronics Co., Ltd.

Chang-eun Yoo

Kyu-youn Hwang

Hun-joo Lee

Joon-Ho Kim

Hee-kyun Lim

Jong-myeon Park

Jun-Hong Min

Young-rok Kim

Ki-woong Han

Jeong-gun Lee

Jeo-young Shim

Soo-suk Lee

Nam Huh

Sung-young Jeong

In-ho Lee

Soo-min Ma

Sung-ouk Jung

Myo-yong Lee

Jae-ho You

Kwang-ho Cheong

Yeon-ja Cho

Ga-hee Kim

Kak Namkoong

Kyu-sang Lee

Won-seok Chung

Kyu-tae Yoo

Young-a Kim

Young-Sun Lee

Ki-eun Kim

Yeon-jeong Kim

Kyu-Youn Hwang

Jun-hong Min

Hyun-ju Kang

Ye-ryoung Yong

Young-nam Kwon

Christopher Hansung Ko

Shin-i Yoo

Hun-Joo Lee

Kyung-yeon Han

Sang-hyun Peak

Seung-yeon Yang

Sung-yung Jeong

Myoung-soon Kim

Jung-won Keum

Hee-Kyun Lim

Jeo-Young Shim

Sung-Young c/o Samsung Advanced Institute Of Technology Jeong

Provided are nucleic acid structures suitable for reproducible Raman spectroscopy, methods of preparing the same, and methods of detecting a target material using the nucleic acid structures, whereby various target materials may be analyzed by using reproducible Raman spectroscopy.

Nucleic acid structure complex including nucleic acids, Raman-active molecules, and metal particles, method of preparing the same, and method of detecting target material by using the nucleic acid structure complex

A composition, a kit, and a method of isolating a vesicle from a sample using a compound comprising zwitterion moieties, which may be used to analyze vesicles, and proteins, glycoprotein, lipids, or nucleic acids thereof.

Compositions, kits, and methods for isolating vesicles

A solid support comprising a polymer that includes a group having at least two hydroxyls or a zwitterionic group and a method of using the same.

Polymer including group having at least two hydroxyls or zwitterionic group and use thereof

Provided are compositions, kits, and methods for separating cells including complexes of at least one type of linker capable of binding to an antibody or antigen binding fragment and a solid phase.

Compositions and kits for separating cells and method of separating cells using the same

A method for forming a filter in a fluid flow path in a microfluidic device is provided. The method includes introducing a photopolymerization reaction solution into the microfluidic device; and performing polymerization of photopolymerization reaction solution to form a filter in the fluid flow path in a microfluidic device.

Method of forming filter in fluid flow path in microfluidic device

Provided herein is a method and apparatus for disrupting cells and purifying nucleic acids in a single chip. The method comprises irradiating a chip with a laser beam, wherein the chip comprises a solid support on which a cell lysis enhancing metal oxide layer, and a cell binding metal oxide layer have been deposited.

Method and apparatus for disrupting cells and purifying nucleic acid using a single chip

A field effect transistor for detecting an analyte having a thiol group includes a substrate, a source region and a drain region formed apart from each other on the substrate, the source region and the drain region being doped such that a polarity of the source and drain region is opposite to a polarity of the substrate, a channel region disposed between the source region and the drain region, an insulating layer formed of an electrically insulating material and disposed on the channel region, a gold layer disposed on the insulating layer and a reference electrode disposed apart from the gold layer.

Field effect transistor comprising gold layer, microfluidic device comprising the field effect transistor, and method of detecting analyte having thiol group using the field effect transistor and the microfluidic device

Provided are a microarray substrate comprising a solid substrate coated with a chemical having a functional residue represented by Formula 1 or 2 below, a method of analyzing a biomolecule using the microarray substrate, and a lab-on-a-chip comprising the microarray substrate: 

Microarray substrate, method of use, and products comprising the microarray substrate

This invention provides a microfluidic device comprising an inlet and an outlet which are connected with each other through a microchannel, wherein a polymerized hydrophobic porous polymer is bonded to magnetic beads and to the walls of the microchannel. The invention is further directed to methods of making and using the microfluidic device.

Microfluidic device including a microchannel with a hydrophobic porous polymer bonded to walls thereof and to a magnetic bead, and methods of making and using the device

Provided is a method of controlling the pH of a solution using electrolysis in a microfluidic device comprising an electrolysis device including an anode chamber, a cathode chamber, and a partition membrane between the anode chamber and the cathode chamber, wherein the anode chamber includes an inlet and an outlet through which an anode chamber solution enters and is discharged from the anode chamber, respectively, and an electrode, and the cathode chamber includes an inlet and an outlet through which a cathode chamber solution enters and is discharged from the cathode chamber, respectively, and an electrode. The method includes: flowing the anode chamber solution containing a compound having a lower standard oxidation potential than water into the anode chamber through the inlet of the anode chamber; flowing the cathode chamber solution containing a compound having a lower standard reduction potential than water into the cathode chamber through the inlet of the cathode chamber; applying voltage between the electrode in the anode chamber and the electrode in the cathode chamber to induce electrolysis in the anode chamber and the cathode chamber; and mixing equal volumes of the acidic anode-electrolyzed solution and the basic cathode-electrolyzed solution, wherein the volumes of the cathode chamber and the anode chamber are controlled in a predetermined ratio according to a target pH of a solution obtained by mixing the acidic anode-electrolyzed solution and the basic cathode-electrolyzed solution.

Method of controlling pH of electrolyzed solution using microfluidic device including electrolysis device

A method and apparatus for a rapid disruption of cells or viruses using micro magnetic beads and a laser are provided. According to the method and apparatus for a rapid disruption of cells or viruses using micro magnetic beads and a laser, cell lysis within 40 seconds is possible, the apparatus can be miniaturized using a laser diode, a DNA purification step can be directly performed after a disruption of cells or viruses, and a solution containing DNA can be transferred to a subsequent step after cell debris and beads to which inhibitors of a subsequent reaction are attached are removed with an electromagnet. In addition, by means of the cell lysis chip, an evaporation problem is solved, vibrations can be efficiently transferred to cells through magnetic beads, a microfluidics problem on a rough surface is solved by hydrophobically treating the inner surface of the chip, and the cell lysis chip can be applied to LOC.

Method and apparatus for the rapid disruption of cells or viruses using micro magnetic beads and laser

Provided is a method of isolating nucleic acid from cells using a single surface, wherein a compound represented by Formula 1 is bound to the surface. Also provided are an apparatus for isolation of nucleic acids, and a bead for isolating nucleic acids.

Method and apparatus for isolating and purifying nucleic acid using a single surface

Provided are a method of isolating a nucleic acid from a sample and a solid material for isolating the nucleic acid which can be used for the above method. The method includes contacting the sample with a bifunctional material containing an amino group and a carboxyl group at a first pH to bind the nucleic acid to the bifunctional material, the bifunctional material being positively charged at the first pH; and releasing the nucleic acid at a second pH which is higher than the first pH.

Method of isolating a nucleic acid using a material containing an amino group and a carboxyl group and positively charged at a first pH and a solid material for nucleic acid isolation used for the method

A method of sequentially performing concentration and amplification of nucleic acid in a single micro chamber includes: introducing a nucleic acid-containing sample and a solution including a kosmotropic salt to a micro chamber having a hydrophilic interior surface to concentrate the nucleic acid by binding the nucleic acid on the interior surface of the micro chamber; and performing a polymerase chain reaction (PCR) by adding a PCR mixture to the chamber. Since the nucleic acid is reversibly bound to the interior surface of the micro chamber, PCR yield is higher compared with a surface of aluminum oxide in which irreversible binding occurs. In addition, all processes are sequentially performed in a single micro chamber so that the number of samples, consumables, time, and labor for treatment and analysis can be reduced, detection sensitivity can be improved, and risk of sample cross contamination significantly reduced without sample loss by eliminating transporting of the sample. A complete automated system for concentration and amplification of nucleic acid is thus readily provided.

Method and apparatus for concentrating and amplifying nucleic acid in single micro chamber

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Seoul, South Korea

Chang-eun Yoo